Abstract
SEVERAL daily drug-susceptibility rhythms have been reported in rodents1–12. This report demonstrates the daily pattern in susceptibility to D-amphetamine sulphate as measured by percentage of mortality for normal rats housed in a light-dark (LD) environment, for rats maintained in continuous illumination (LL) and for blinded rats kept in continuous darkness (DD).
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SCHEVING, L., VEDRAL, D. & PAULY, J. Daily Circadian Rhythm in Rats to D-Amphetamine Sulphate: Effect of Blinding and Continuous Illumination on the Rhythm. Nature 219, 621–622 (1968). https://doi.org/10.1038/219621a0
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DOI: https://doi.org/10.1038/219621a0
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