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Insensitivity of Mitochondrial RNA Synthesis to Mengovirus Infection in CHO Cells

Abstract

IN animal cells, RNA is synthesized both in the nuclei and the mitochondria, and synthesis is inhibited by infection with certain viruses. Working with Chinese hamster ovary (CHO) cells, we have been able to show that, in the initial stages of infection with Mengovirus, nuclear synthesis is inhibited but mitochondrial synthesis is not.

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References

  1. Nass, N. M. K., Science, 165, 25 (1969).

    Article  ADS  CAS  Google Scholar 

  2. Attardi, G., and Attardi, B., Proc. US Nat. Acad. Sci., 58, 1051 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Dawid, I., Fed. Proc., 28, 349 (1969).

    Google Scholar 

  4. Perry, R., Exp. Cell Res., 29, 400 (1963).

    Article  CAS  Google Scholar 

  5. Roberts, W. K., and Newman, J., J. Mol. Biol., 20, 63 (1966).

    Article  CAS  Google Scholar 

  6. Penman, S., Vesco, C., and Penman, M., J. Mol. Biol., 34, 49 (1968).

    Article  CAS  Google Scholar 

  7. Vesco, C., and Penman, S., Proc. US Nat. Acad. Sci., 62, 218 (1969).

    Article  ADS  CAS  Google Scholar 

  8. Zylber, E., and Penman, S., J. Mol. Biol. (in the press).

  9. Knight, E., Biochemistry (in the press).

  10. Zylber, E., Vesco, C., and Penman, S., J. Mol. Biol., 44, 195 (1969).

    Article  CAS  Google Scholar 

  11. McCormick, W., and Penman, S., Virology, 31, 135 (1967).

    Article  CAS  Google Scholar 

  12. Franklin, R., and Baltimore, D., Cold Spring Harbor Symp. Quant. Biol., 27, 175 (1962).

    Article  CAS  Google Scholar 

  13. Willems, M., Wagner, E., Laing, R., and Penman, S., J. Mol. Biol., 32, 211 (1968).

    Article  CAS  Google Scholar 

  14. Smith, A. E., and Marcker, K. A., J. Mol. Biol., 38, 241 (1968).

    Article  CAS  Google Scholar 

  15. Nass, N. M. K., and Buck, C. A., Proc. US Nat. Acad. Sci., 62, 506 (1968).

    Article  ADS  Google Scholar 

  16. Galper, J. B., and Darnell, J. E., Biochem. Biophys. Res. Commun., 34, 205 (1969).

    Article  CAS  Google Scholar 

Download references

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VESCO, C., PENMAN, S. Insensitivity of Mitochondrial RNA Synthesis to Mengovirus Infection in CHO Cells. Nature 224, 1021–1023 (1969). https://doi.org/10.1038/2241021a0

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