Abstract
SEVERAL research units have studied the genetic mechanisms controlling the synthesis of immunoglobulins and its alteration in hypogammaglobulinaemia. Fudenberg et al.1 investigated Gm and Inv groups in families with agammaglobulinaemia, and suggested the involvement of two genes in the synthesis of an immunoglobulin: one controlling the synthesis of the heavy chains, the other that of the light chains. Burtin et al.2 applied the same principle in their studies on “non sex-linked atypic hypogammaglobulinaemia”, and postulated the existence of abnormal alleles leading to an impaired synthesis of the heavy chains of one or several immunoglobulins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fudenberg, H. H., Heremans, J. F., and Franklin, E. C., Ann. Inst. Pasteur, 104, 155 (1963).
Burtin, P., Buffe, D., and Grabar, P., Ann. Inst. Pasteur, 106, 519 (1964).
Grey, H. M., and Kunkel, H. G., J. Exp. Med., 120, 253 (1964).
Terry, W. D., and Fahey, J. L., Science, 146, 400 (1964).
Rivat, L., Ropartz, C., Burtin, P., and Karitzky, D., Vox Sang., 17, 5 (1969).
Yount, W. J., Hong, R., Seligmann, M., and Kunkel, H. G., J. Clin. Invest., 48, 92a (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RIVAT, L., ROPARTZ, C., BURTIN, P. et al. Genetic Control of Deficiencies in γG Subclasses observed among Families with Hypogammaglobulinaemia. Nature 225, 1136–1137 (1970). https://doi.org/10.1038/2251136a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2251136a0
This article is cited by
-
Human IgG subclasses in health and disease(A review) Part II
La Ricerca in Clinica e in Laboratorio (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.