Abstract
ACTIVATION of the complement cascade (C1–C9) by the classic or alternate pathways is associated with the development of several biological activities1. These include the elaboration of chemotactic factors (C3a, C5a, and a trimolecular complex C&5,6,7bar;), opsonic activity associated with the formation of C3b from the third component, anaphylatoxin activity associated with the formation of C3a and C5a from the third (C3) and fifth (C5) components, and lysis of certain cells after the formation of lesions at the cell surface associated with fixation of the eighth (C8) and ninth (C9) components. We have detected another activity which follows intravascular activation of the complement cascade with the elaboration of the low molecular weight factor that produces an immediate neutropenia followed by marked neutrophilia.
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References
Ruddy, S., Gigli, I., and Austin, K. F., New Engl. J. Med., 248, 489, 545, 592, 624 (1972).
Ballow, M., and Cochrane, C. G., J. Immun., 103, 944 (1969).
Lachmann, P. J., Hobart, N. J., and Aston, W. P., in Experimental immunology, second ed. (edit. by Weir, P. M.), (Blackwell, Oxford, in the press).
Brown, D. L., dissertation, Univ. Cambridge (1972).
Cochrane, C. G., Müeller-Eberhard, H. J., and Akin, B. S., J. Immun., 105, 55 (1970).
Andrewes, F. W., Lancet, i, 8 (1910).
McCabe, W. R., New Engl. J. Med., 288, 21 (1973).
McKay, D. G., Thrombos. Diathes. Haemorrah., 22, 11 (1973).
Gilbert, D. N., Barnett, J. A., and Sanford, J. P., J. clin. Invest., 52, 406 (1973).
Dodds, W. J., and Pickering, R. J., Blood, 40, 400 (1972).
Rother, K., Eur. J. Immun., 2, 550 (1972).
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MCCALL, C., DE CHATELET, L., BROWN, D. et al. New biological activity following intravascular activation of the complement cascade. Nature 249, 841–843 (1974). https://doi.org/10.1038/249841a0
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DOI: https://doi.org/10.1038/249841a0
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