Abstract
IN several animal species, C-type oncogenic RNA viruses (oncornaviruses) cause malignant tumours of mesodermal origin, such as leukaemia, lymphomas and different kinds of sarcoma1. C-type oncornaviruses have rarely been observed in human mesenchymal neoplasms using electron microscopy2,3, but it has been claimed that molecular-biological methods can demonstrate in the tumours the presence of entities, the nucleic acids of which have sequences in common with the genomes of known mammalian oncornaviruses4–7. There have also been claims that C-type viruses can be detected in tissue cultures of human tumours8–10, although it seems that a contamination with an animal virus had occurred in these cases. Recently11 an agent with type C RNA tumour virus characteristics has been isolated from cultured human acute myelogenous leukaemia cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gross, L., Oncogenic Viruses second ed., (Pergamon, Oxford, 1970).
Morton, D. L., Hall, W. T., and Malmgren, R. A., Science, 165, 813 (1969).
Stewart, S. E., et al., J. natn. Cancer Inst., 48, 273 (1972).
Kufe, D., Hehlmann, R., and Spiegelman, S., Science, 175, 182 (1972).
Hehlmann, R., Kufe, D., and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 69, 435 (1972).
Hehlmann, R., Kufe, D., and Spiegelman, S., Proc. natn. Acad. Sci. U.S.A., 69, 1727 (1972).
Gallo, R. C., Miller, N. R., Saxinger, W. C., and Gillespie, D., Proc. natn. Acad. Sci. U.S.A., 70, 3219 (1973).
Priori, E. S., Dmochowski, L., Myers, B., and Wilbur, J. R., Nature new Biol., 232, 61 (1971).
McAllister, R. M., et al., Nature new Biol., 235, 3 (1972).
Stewart, S. E., Kasnic, G., Draycott, C., and Ben, T., Science, 175, 198 (1972).
Gallagher, R. E., and Gallo, R. C., Science, 187, 350 (1975).
Eilber, F. R., and Morton, D. L., J. natn. Cancer Inst., 44, 651 (1970).
Giraldo, G., et al., J. exp. Med., 133, 454 (1971).
Priori, E. S., Wilbur, J. R., and Dmochowski, L., J. natn. Cancer Inst., 46, 1299 (1971).
Moore, M., Witherow, P. J., Price, C. H. J., and Clough, S. A., Int. J. Cancer, 12, 428 (1973).
Geering, G., Aoki, T., and Old, L. J., Nature, 226, 265 (1970).
Gilden, R. V., and Oroszlan, S., Proc. natn. Acad. Sci. U.S.A., 69, 1021 (1972).
Schäfer, W., Pister, L., Hunsmann, G., and Moennig, V., Nature new Biol., 245, 75 (1973).
Levine, E. M., Expl Cell Res., 74, 99 (1972).
Nelson-Rees, W. A., Flandermeyer, R. R., and Hawthorne, P. K., Science, 184, 1093 (1974).
Geering, G., Old, L. J., and Boyse, E. A., J. exp. Med., 124, 753 (1966).
Hilgers, J., Nowinski, R. C., Geering, G., and Hardy, W., Cancer Res., 32, 98 (1972).
Grollé, P. F., Bentvelzen, P., and Noord, M. J. van, Biomedicine Expr., 19, 148 (1973).
Deinhardt, F., Wolfe, L., Massey, R., Hoekstra, J., and McDonald, R., Bibl. Haematol., 39, 258 (1973).
Gilden, R. V., Oroszlan, S., Summers, M., and Davis, J., in Possible Episomes in Eukaryotes (edit. by Silvestri, L. G.,) 98 (North-Holland, Amsterdam, 1973).
Chenaille, Ph, Tavitian, A., and Boiron, M., Eur. J. Cancer, 3, 511 (1968).
Calafat, J., and Hageman, P. C., J. gen. Virol., 14, 103 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ZURCHER, C., BRINKHOF, J., BENTVELZEN, P. et al. C-type virus antigens detected by immuno-fluorescence in human bone tumour cultures. Nature 254, 457–459 (1975). https://doi.org/10.1038/254457a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/254457a0
This article is cited by
-
RNA-tumoriviruses, oncogenes, and their possible role in human carcinogenesis
Klinische Wochenschrift (1983)
-
Characterization of newly established human osteosarcoma cell line, LM-1
In Vitro (1981)
-
Human leukemia viruses? RNA tumor viruses, human malignancies, and concepts of viral carcinogenesis
Blut (1980)
-
Establishment and characterization of C-type RNA virus-producing cell lines from radiation-induced murine osteosarcomas
Journal of Cancer Research and Clinical Oncology (1979)
-
Electron microscopical and biochemical investigations on retra viruses in spleen tissue in malignancy
Journal of Cancer Research and Clinical Oncology (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.