Abstract
SYNTHESIS of ribosomal RNA and its transfer to the cytoplasm have been implicated repeatedly in the processing and transport of informational RNA and the regulation of enzyme activities1–4. We have studied the involvement of rRNA in the RNA synthesis-dependent induction of the microsomal enzyme, aryl hydrocarbon hydroxylase5; the activity of this mixed-function oxygenase in mammalian tissues and in cells in culture increases many-fold after a few hours exposure to a polycyclic hydrocarbon5–10. The induction process requires de novo protein synthesis and DNA-dependent RNA synthesis5,9,11 and can be influenced by post-transcriptional regulatory mechanisms9,12.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Billing, R. J., Barbiroli, B., and Smellie, R. M. S., Biochem. J., 112, 563–569 (1969).
Tata, J. R., Nature, 219, 331–337 (1968).
Sidebottom, E., and Harris, H., J. Cell Sci., 5, 351–364 (1969).
Deak, I., Sidebottom, E., and Harris, H., J. Cell Sci., 11, 379–391 (1972).
Wiebel, F. J., Matthews, E. J., and Gelboin, H. V., J. biol. Chem., 247, 4711–4717 (1972).
Conney, A. H., Pharmac. Rev., 19, 317–366 (1967).
Nebert, D. W., and Gelboin, H. V., J. biol. Chem., 243, 6242–6249 (1968).
Nebert, D. W., and Gelboin, H. V., Archs Biochem. Biophys., 134, 76–89 (1969).
Whitlock, J. P., Jr, and Gelboin, H. V., J. biol. Chem., 248, 6114–6121 (1973).
Wiebel, F. J., Gelboin, H. V., and Coon, H. G., Proc. natn. Acad. Sci. U.S.A., 69, 3580–3584 (1972).
Nebert, D. W., and Gelboin, H. V., J. biol. Chem., 245, 160–168 (1970).
Gelboin, H. V., and Wiebel, F. J., Ann. N. Y. Acad. Sci., 179, 529–547 (1971).
Toniolo, D., Meiss, H. K., and Basilico, C., Proc. natn. Acad. Sci. U.S.A., 70, 1273–1277 (1973).
Penman, S., J. molec. Biol., 17, 117–130 (1966).
Perry, R. P., Proc. natn. Acad. Sci. U.S.A., 48, 2179–2186 (1962).
Tomkins, G. M., et al., Science, 166, 1474–1484 (1969); Nature new Biol., 239, 9–14 (1972).
Jacob, S. T., Scharf, M. B., and Vesell, E. S., Proc. natn. Acad. Sci. U.S.A., 71, 704–707 (1974).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).
Bader, J. P., and Steck, T. L., J. Virol., 4, 454–459 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WIEBEL, F., BADER, J. & GELBOIN, H. Enzyme induction in mammalian cells defective in 28S ribosomal RNA formation. Nature 259, 331–333 (1976). https://doi.org/10.1038/259331a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/259331a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
