Abstract
ALEUTIAN DISEASE (AD), which affects certain Mustelidae, is a persistent viral infection with development of non-neutralising antibody and gammapathy1–3. Some of the antigens developed in the course of AD are detectable by counter-immunoelectrophoresis (CEP) using sera from chronically infected mink. We have obtained evidence of two antigenic forms, Ag-1 and Ag-2, which have been characterised by molecular size, primary protein subunit components and by electron microscopy. Hollow ring-like structures, similar to those described with such viruses as ϕX1744, rat virus, Haden, adeno-associated virus and others5, were found associated with the AD virus (ADV) and seem to be the predominant antigenic component of Ag-1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Helmboldt, C. F., and Jungherr, E. L., Am. J. vet. Res., 20, 384–388 (1975).
Bloom, M. E., Race, R. E., Hadlow, W. J., and Chesebro, B., J. Immun., 115, 1034–1037 (1975).
Kenyon, A. J., Slow, Latent and Temperate Virus Infections, NINDB Monograph 2, 321–328 (1966).
Tromans, W. J., and Home, R. W., Virology, 15, 1–7 (1975).
Hoggan, M. D., Comparative Virology, 43–79 (Academic, New York, 1971).
Cho, H. J., and Ingram, D. G., J. Immun., 108, 555–557 (1972).
Cho, H. J., and Ingram, D. G., Nature new Biol., 243, 174–176 (1973).
Rueckert, R. R., Comparative Virology, 255 (Academic, New York, 1971).
Backman, P. A., Hoggan, M. D., Melnick, J. L., Pereira, H. G., and Vago, C., Intervirology, 5, 83–92 (1975).
Greenwood, F. E., Hunter, W. M., and Glover, J. S., Biochem. J., 89, 114–123 (1963).
Crestfield, A. M., Moore, S., and Stein, W. H., J. biol. Chem., 238, 622–627 (1963).
Laemmli, U. K., Nature, 227, 680–685 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NOTANI, G., HAHN, E., SARKAR, N. et al. Characterisation of Aleutian disease antigens. Nature 261, 56–58 (1976). https://doi.org/10.1038/261056a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/261056a0
This article is cited by
-
Demonstration of non-degraded aleutian disease virus (ADV) proteins in lung tissue from experimentally infected mink kits
Archives of Virology (1986)
-
Serological analyses of different mink Aleutian disease virus strains
Archives of Virology (1984)
-
Properties of Aleutian disease virus assayed with feline kidney cells
Archives of Virology (1977)
-
Preparation of Antigen for the Counterimmunoelectrophoretic Test for Plasmacytosis in Mink*
Acta Veterinaria Scandinavica (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
