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gag Gene of mammalian type-C RNA tumour viruses

Abstract

The translation product of the gag gene of mammalian type-C RNA viruses is a 65,000–68,000 molecular weight precursor polypeptide (Pr65) whose cleavage leads to the formation of four virion proteins, p30, p15, p12 and p10. An immunological approach has been used to establish the arrangement of the sequences coding for these proteins within the viral genome as (5′) p15–p12–p30–p10 (3′).

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References

  1. Cold Spring Harb. Symp. quant. Biol., 39, part 2 (1975).

  2. Vogt, V. M., and Eisenman, R., Proc. natn. Acad. Sci. U.S.A., 70, 1734–1738 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Der Helm, K. V., and Duesberg, P. H., Proc. natn. Acad. Sci. U.S.A., 72, 614–618 (1975).

    Article  ADS  Google Scholar 

  4. Stephenson, J. R., Tronick, S. R., and Aaronson, S. A., Cell, 6, 543–548 (1975).

    Article  CAS  Google Scholar 

  5. Oskarson, M. K., et al., Proc. natn. Acad. Sci. U.S.A., 72, 2380–2384 (1975).

    Article  ADS  Google Scholar 

  6. Arcement, L. J., Karshin, W. L., Naso, R. B., Jamjoom, G., and Arlinghaus, R. B., Virology, 69, 763–774 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. Salden, M., Asselbergs, F., and Bloemendal, H., Nature, 259, 696–699 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Baltimore, D., Cold Spring Harb. Symp. quant. Biol., 39, 1187–1200 (1975).

    Article  PubMed  Google Scholar 

  9. Wang, L. H., Duesberg, P. H., Kawai, S., and Hanafusa, H., Proc. natn. Acad. Sci. U.S.A., 73, 447–451 (1976).

    Article  ADS  CAS  Google Scholar 

  10. Hanafusa, H., in Cancer: A Comprehensive Treatise. (edit. by Becker, F. F.), 2 49–90 (Plenum, New York, 1975).

    Book  Google Scholar 

  11. Vogt, P. K., in Comprehensive Virology, (edit by Fraenkel-Conrat, H., and Wagner, R. R.) (Plenum, New York, in the press).

  12. Aaronson, S. A., and Stephenson, J. R., Biochim. biophys. Acta Rev. Cancer (in the press).

  13. Joho, R. H., Billeter, M. A., and Weissman, C., Proc. natn. Acad. Sci. U.S.A., 72, 4772–4776 (1975).

    Article  ADS  CAS  Google Scholar 

  14. Vogt, V. M., Eisenman, R., and Diggelmann, H., J. molec. Biol., 96, 471–493 (1975).

    Article  CAS  PubMed  Google Scholar 

  15. Zaane, D. V., Gielkens, A. L. J., Dekker-Michielsen, M. J. A., and Bloemers, H. P. J., Virology, 67, 544–552 (1975).

    Article  Google Scholar 

  16. Bassin, R. H., Tuttle, N., and Fischinger, P. J., Int. J. Cancer, 6, 95–107 (1970).

    Article  CAS  PubMed  Google Scholar 

  17. Tronick, S. R., Stephenson, J. R., and Aaronson, S. A., Virology, 54, 199–206 (1973).

    Article  CAS  PubMed  Google Scholar 

  18. Aaronson, S. A., Stephenson, J. R., Hino, S., and Tronick, S. R., J. Virol., 16, 1117–1123 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Strand, M., and August, J. T., J. biol. Chem., 248, 5627–5633 (1973).

    CAS  PubMed  Google Scholar 

  20. Hino, S., Stephenson, J. R., and Aaronson, S. A., J. Immun., 115, 922–927 (1975).

    CAS  PubMed  Google Scholar 

  21. Oroszlan, S., Huebner, R. J., and Gilden, R. V., Proc. natn. Acad. Sci. U.S.A., 68, 901–904 (1971).

    Article  ADS  CAS  Google Scholar 

  22. Parks, W. P., and Scolnick, E. M., Proc. natn. Acad. Sci. U.S.A., 69, 1766–1770 (1972).

    Article  ADS  CAS  Google Scholar 

  23. Strand, M., Wilsnack, R., and August, J. T., J. Virol., 14, 1575–1583 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Barbacid, M., Stephenson, J. R., and Aaronson, S. A., J. Biol. Chem. 251, 4859–4866 (1976).

    CAS  PubMed  Google Scholar 

  25. Scolnick, E. M., et al., Proc. natn. Acad. Sci. U.S.A., 72, 4650–4654 (1975).

    Article  ADS  CAS  Google Scholar 

  26. Frankel, A. E., Neubauer, R. L., and Fischinger, P. J., J. Virol., 18, 481–490 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Aaronson, S. A., Bassin, R. H., and Weaver, C., J. Virol., 9, 701–704 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Peebles, P. T., Gerwin, B. J., and Scolnick, E. M., Virology, 70, 313–323 (1976).

    Article  CAS  PubMed  Google Scholar 

  29. Peters, R. L., Rabstein, L. S., Vanvleck, R., Kelloff, G. J., and Heubner, R. J., J. natn. Cancer Inst., 53, 1725–1129 (1974).

  30. Wolfe, L. G., Smith, R. K., and Deinhardt, F., J. natn. Cancer Inst., 48, 1905–1908 (1972).

    CAS  Google Scholar 

  31. Abelson, H. T., and Rabstein, L. D., Cancer Res., 30, 2213–2222 (1970).

    CAS  PubMed  Google Scholar 

  32. Scher, C. D., and Siegler, R., Nature, 253, 729–731 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Huebner, R. J., et al., Proc. natn. Acad. Sci. U.S.A., 67, 366–376 (1970).

    Article  ADS  CAS  Google Scholar 

  34. Parks, W. P., Livingston, D. M., Todaro, G. J., Benveniste, R. E., and Scolnick, E. M., J. exp. Med., 137, 622–635 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Stephenson, J. R., Tronick, S. R., Reynolds, R. K., and Aaronson, S. A., J. exp. Med., 139, 427–438 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Temin, H. M., Adv. Cancer Res., 19, 48–105 (1974).

    Google Scholar 

  37. Fleissner, E., J. Virol., 8, 778–785 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Fan, H., and Baltimore, D., J. molec. Biol., 80, 93–117 (1973).

    Article  CAS  PubMed  Google Scholar 

  39. Tsuchida, N., and Green, M., Virology, 59, 258–265 (1974).

    Article  CAS  PubMed  Google Scholar 

  40. August, J. T., Bolognesi, D. P., Fleissner, E., Gilden, R. V., and Nowinski, R. C., Virology, 60, 595–601 (1974).

    Article  CAS  PubMed  Google Scholar 

  41. Lilly, F., and Steeves, R., Biochim. biophys. Acta Rev. Cancer, 355, 105–118 (1974).

    Article  CAS  Google Scholar 

  42. Bolognesi, D. P., Huper, G., Green, R. W., and Graf, T., Biochim. biophys. Acta Rev. Cancer, 355, 220–235 (1974).

    Article  CAS  Google Scholar 

  43. Stephenson, J. R., Barbacid, M., Tronick, S. R., Hino, S., and Aaronson, S. A., in Cancer Research: Cell Biology, Molecular Biology and Tumor Virology (edit. by Gallo, R.) (CRC Press, Cleveland, in the press).

  44. Peebles, P. T., Fischinger, P. J., Bassin, R. H., and Papageorge, A. G., Nature new Biol., 242, 98–101 (1973).

    Article  CAS  PubMed  Google Scholar 

  45. Greenwood, F. C., Hunter, W. M., and Glover, J. S., Biochem. J., 89, 114–123 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Lowry, O. K., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).

    CAS  PubMed  Google Scholar 

  47. Hino, S., Stephenson, J. R., and Aaronson, S. A., J. Virol., 18, 933–941 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Peebles, P. T., Gerwin, B. I., Papageorge, A. G., and Smith, S. G., Virology, 67, 344–355 (1975).

    Article  CAS  PubMed  Google Scholar 

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Barbacid, M., Stephenson, J. & Aaronson, S. gag Gene of mammalian type-C RNA tumour viruses. Nature 262, 554–559 (1976). https://doi.org/10.1038/262554a0

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