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Echovirus 12-induced host cell shutoff is prevented by rhodanine

Nature volume 267, pages 370–371 (1977)Cite this article

Abstract

INFECTION of animal cells with picornaviruses results in inhibition of host cell RNA and protein synthesis shortly after infection, as was shown with members of the cardiovirus group1–3, with poliovirus4–6, and with foot-and-mouth disease virus7. The molecular mechanism of this so-called shutoff is not well understood; however, it seems to require protein synthesis early in infection2,8,9, but no viral RNA replication9–11. We report here that 2-thio-4-oxothiazolidine (rhodanine), at a concentration which inhibits selectively the uncoating of echovirus 12 in GMK cells also inhibits the virus-induced shutoff of GMK cell protein synthesis.

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Authors and Affiliations

  1. Institut für Virologie der Universität zu Köln, Fürst-Pückler-Strasse 56, 5000, Köln, 41, BRD

    BRIGITTE ROSENWIRTH & HANS J. EGGERS

Authors
  1. BRIGITTE ROSENWIRTH
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  2. HANS J. EGGERS
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ROSENWIRTH, B., EGGERS, H. Echovirus 12-induced host cell shutoff is prevented by rhodanine. Nature 267, 370–371 (1977). https://doi.org/10.1038/267370a0

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