Abstract
During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Maaløe, O. & Kjeldgaard, N. O. Control of Macromolecular Synthesis (W. A. Benjamin, New York, 1966).
Mitchison, J. M. Expl Cell Res. 13, 244–262 (1957).
Mitchison, J. M. & Creanor, J. J. Cell Sci. 5, 373–391 (1969).
Wain, W. H. & Staatz, W. D. Expl Cell Res. 81, 269–278 (1973).
Fraser, R. S. S. & Moreno, F. J. Cell Sci. 21, 497–521 (1976).
Mitchison, J. M. & Creanor, J. Expl Cell Res. 69, 244–247 (1971).
Nurse, P. Nature 256, 547–551 (1975).
Mitchison, J. M. & Creanor, J. Expl Cell Res. 67, 368–374 (1971).
Stebbing, N. J. Cell Sci. 9, 701–717 (1971).
Fantes, P. A., Grant, W. D., Pritchard, R. H., Sudbery, P. E. & Wheals, A. E. J. theor. Biol. 50, 213–244 (1975).
Pritchard, R. H., Barth, P. T. & Collins, J. Svmp. Soc. gen. Microbiol. 19, 263–297 (1969).
Cashel, M. & Gallant, J. Ribosomes (eds Normura, M., Tissieres, A. & Lengyel, P.), 733–745 (Cold Spring Harbor Laboratory, 1974).
Holliday, R. & Pugh, J. E. Science 187, 226–232 (1975).
Paul, J. & Gilmour, R. S. J. molec. Biol. 34, 305–316 (1968).
Vaughan, S. Nature 269, 86–87 (1977).
Courtright, J. B. Adv. Genet. 18, 249–314 (1976).
Halvorson, H. O., Carter, B. L. A. & Tauro, P. Meth. Enzym. 21, 462–471 (1970).
Fraser, R. S. S. & Carter, B. L. A. J. molec. Biol. 104, 223–242 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fraser, R., Nurse, P. Novel cell cycle control of RNA synthesis in yeast. Nature 271, 726–730 (1978). https://doi.org/10.1038/271726a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/271726a0
This article is cited by
-
A protocol for isolation and visualization of yeast nuclei by scanning electron microscopy (SEM)
Nature Protocols (2007)
-
Role of pescadillo in the transformation and immortalization of mammalian cells
Oncogene (2004)
-
Coordination of growth with cell division: Regulation of synthesis of RNA during the cell cycle of the fission yeast Schizosaccharomyces pombe
Molecular and General Genetics MGG (1983)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.