Abstract
Pasteur, Vallery Radot, Halpen and Haltzer1 assert that an anti-histaminic-inhibited shock has no tachiphylactic action ; more precisely, rabbits protected from a shock by an anti-hystaminic died of shock after another dose of serum was administered some days later. They considered the results as an argument in favour of their theory, namely, that anti-histaminics prevent antigen-antibody reactions and thus leave the tissues free from antibodies to react with a subsequent dose of antigen. We have obtained contrary results, however, in analogous experiments. Thirteen guinea pigs have been sensitized with 1/10 c.c. of horse serum by intraperitoneal injection. After fifteen days they were given 1 c.c. of the same serum by intracardiac injection. Eleven were given 5 mgm. of an anti-histaminic ('Dimetina', kindly furnished by Le Petit Co.) by intraperitoneal injection 10 min. before the shock treatment. All of them survived, whereas the other two died.
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C.R. Soc. Biol. ( March 1947).
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TRAINA, V., ALEKSANDROWICZ, D. Effects of a Serum Injection after an Anti-Histaminic-Inhibited Shock. Nature 163, 364 (1949). https://doi.org/10.1038/163364b0
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DOI: https://doi.org/10.1038/163364b0
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