Abstract
IN a previous communication1, we have described the morphological and cytological modifications of staphylococci after treatment with penicillin. Since then, we have investigated the effect of this antibiotic on various bacteria: E. coli, B. anthracis, and Salmonella, Proteus, Pasteurella spp. All our observations show that penicillin reduces considerably or completely inhibits the cytoplasmic divisions, whereas the nuclear divisions take place at a normal rhythm, at least during a certain length of time. This leads to the appearance of giant forms ('large bodies') containing numerous normal or abnormal nuclei. The results are extremely clear in bacilli, and the details have been described elsewhere2.
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References
Tulasne, R., and Vendrely, R., Nature, 161, 316 (1948).
Tulasne, R., Vendrely, R., and Minck, R., C.R. Soc. Biol., 142, 237 (1948). Tulasne, R., C.R. Soc. Biol., 143, 286 and 289 (1949).
Tulasne, R., and Vendrely, R., Nature, 160, 225 (1947).
Dienes, J. Bact., 56, 445 (1948).
Dienes, personal communication and Proc. 49th General Meeting Soc. of Amer. Bacteriologists, 1949 (in the press).
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TULASNE, R. Existence of L-Forms in Common Bacteria and their Possible Importance. Nature 164, 876–877 (1949). https://doi.org/10.1038/164876b0
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DOI: https://doi.org/10.1038/164876b0
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