Abstract
A MOULD, isolated by Kurung1 in 1944 and considered to be a strain of Aspergillus ustus (Bain.) Thom and Church, was shown to produce a metabolic liquor which possessed a marked antibiotic activity towards Mycobacterium tuberculosis and M. ranæ. Afterwards, Hogeboom and Craig2, by application of a counter-current technique, were able to isolate, from an ethereal extract of this mould and its substrate, two crystalline products, called compound I and compound II, which showed a very high activity against M. ranæ. Doering, Dubos, Noyce and Dreyfus3, using the same strain of mould, isolated a number of chlorine-containing metabolic products, one of which was proved to be identical with Hogeboom and Craig's compound I. Doering et al. proposed the name ‘ustin’ for this compound, established its empirical formula (C19H15O5Cl3) and published a superficial account of some of its chemical properties.
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References
Kurung, J. M., Science, 102, 11 (1945).
Hogeboom, G. H., and Craig, L. C., J. Biol. Chem., 162, 363 (1946).
Doering, W. E., Dubos, R. J., Noyce, D. S., and Dreyfus, R., J. Amer. Chem. Soc., 68, 725 (1946).
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DEAN, F., ROBERTSON, A., ROBERTS, J. et al. Nidulin and ‘Ustin’: Two Chlorine-containing Metabolic Products of Aspergillus nidulans. Nature 172, 344 (1953). https://doi.org/10.1038/172344a0
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DOI: https://doi.org/10.1038/172344a0
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