Abstract
A REVERSAL of aureomycin action by folic acid and, to a lesser extent, vitamin B12 has been observed by us with several micro-organisms. Since aureomycin acts primarily on rapidly growing organisms1 and since the mediation of folic acid and vitamin B12 in nucleic acid synthesis is known2, it was of interest to ascertain the relationship in this respect between these vitamins and the antibiotic.
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References
Hobby, G. L., Bact. Rev., 17, 29 (1953).
Rege, D. V., and Sreenivasan, A., Nature, 166, 1117 (1950).
Pandalai, K. M., and George, M., Curr. Sci., Ind., 16, 312 (1947); Lancet, 256, 955 (1949).
Gale, E. F., in “Selective Toxicity and Antibiotics”, Soc. Exp. Biol., 3, 233 (1949).
Smolens, J., and Vogt, A. B., J. Bact., 66, 140 (1953).
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REGE, D., SREENIVASAN, A. Influence of Folic Acid and Vitamin B12 on the Impairment of Nucleic Acid Synthesis in Lactobacillus casei by Aureomycin. Nature 173, 728–729 (1954). https://doi.org/10.1038/173728b0
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DOI: https://doi.org/10.1038/173728b0
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