Abstract
SOME striking toxic effects have been described for certain antibilharzial compounds1,2,3. These consist of visual impairment and loss of hair in laboratory animals. More recently4, the activity and toxicity of some N-p-aminophenoxy-alkylamides have been described in experimental schistosomiasis. One of these compounds*, 1-p-aminophenoxy-5-phthalimidopentane, (M and B 2948A)(I), has been tested for its effect against liver fluke in sheep and the purpose of this note is to describe the toxic effects observed. When given orally to sheep this compound was observed to produce a remarkable loss of wool. 
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Edge, N. D., Mason, D. F. J., Wien, R., and Ashton, N., Nature, 178, 806 (1956).
Goodwin, L. G., Richards, W. H. G., and Udall, V., Brit. J. Pharmacol., 12, 468 (1957).
Sorsby, A., and Nakajima, A., Brit. J. Opthal., 42, 563 (1958).
Collins, R. F., Davis, M., Edge, N. D., Hill, J., and Turnbull, E. R. (to be published in Brit. J. Pharmacol.).
Hill, J. (private communication).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUGHES, D. Loss of Wool in Sheep caused by 1-p-Amino-phenoxy-5-phthalimidopentane. Nature 184, 1644–1645 (1959). https://doi.org/10.1038/1841644a0
Issue Date:
DOI: https://doi.org/10.1038/1841644a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
