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Anti-Pneumococcus Type XIV Activity of Precipitins from Ricinus communis Seeds

Abstract

A CHEMICAL structure closely similar to type XIV pneumococcus polysaccharide is probably the basic substrate used in the formation of the human A, B, H and Lea blood group specific substances1. Studies of the precipitation of the various blood group specific substances and related materials by Ricinus communis seed extract suggest that the activity of the Ricinus precipitin is directed towards the basic chemical framework of the human blood group substances2–4. It is thus possible that the Ricinus precipitin is actually specific for type XIV pneumococcus polysaccharide. The following experiments were carried out to investigate this possibility.

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References

  1. Watkins, W. M., and Morgan, W. T. J., Vox Sang., 4, N.S. 97 (1959).

  2. Bird, G. W. G., Ph.D. thesis, University of London (1958).

  3. Bird, G. W. G., Brit. Med. Bull., 15, 165 (1959).

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  4. Bird, G. W. G., Vox Sang., 4, N.S. 313 (1959).

  5. Boyd, W. C., and Reguera, R. M., J. Immunol., 62, 333 (1949).

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  6. Ouchterlony, O., Acta Path. Microbiol. Scand., 32, 231 (1953).

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BIRD, G. Anti-Pneumococcus Type XIV Activity of Precipitins from Ricinus communis Seeds. Nature 187, 415–416 (1960). https://doi.org/10.1038/187415a0

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