Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Phosphorylation as a Factor in promoting the Crabtree Effect in the Amytal Ascites Sarcoma of White Mice

Nature volume 188, pages 857–858 (1960)Cite this article

Abstract

CRABTREE1 has demonstrated an inhibition of oxygen consumption in several different malignant tissues following the addition of glucose. Many attempts have since been made, especially during recent years, to explain the mechanism of this phenomenon. Certain workers2,3 regard adenine nucleotides, others4,5 inorganic phosphorus, as responsible for the production of the Crabtree effect and postulate a competition between the oxidative and glycolytic systems for one of these substances. Åcs et al. 6 have suggested that a location of enzyme systems unique for the cells involved also plays some part in producing the inhibitory effect.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Crabtree, H. G., Biochem. J., 23, 536 (1929).

    Article  CAS  Google Scholar 

  2. Chance, B., and Hess, B., Ann. N.Y. Acad. Sci., 63, 1008 (1956).

    Article  ADS  CAS  Google Scholar 

  3. Racker, E., Ann. N.Y. Acad. Sci., 63, 1017 (1956).

    Article  ADS  CAS  Google Scholar 

  4. Brin, O., and McKee, R. W., Cancer Res., 16, 364 (1956).

    CAS  PubMed  Google Scholar 

  5. Wu, E., and Racker, E., Fed. Proc., 16, 274 (1957).

    Google Scholar 

  6. Straub, F. B., Åcs, G., Garro, T., Molnár, J., and Stephanek, O., Acta Phys. Hung., 9, 9 (1956).

    Google Scholar 

  7. Ibsen, K. H., Coe, E. L., and McKee, R. W., Biochim. Biophys. Acta, 30, 384 (1958).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Péterfy-S. Street Hospital, Budapest

    S. BRAUN, M. ERDÉLYI & A. UDVARDY

Authors
  1. S. BRAUN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. ERDÉLYI
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. UDVARDY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRAUN, S., ERDÉLYI, M. & UDVARDY, A. Phosphorylation as a Factor in promoting the Crabtree Effect in the Amytal Ascites Sarcoma of White Mice. Nature 188, 857–858 (1960). https://doi.org/10.1038/188857a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/188857a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing