Abstract
PRESENT methods for the production of Clostridium histolyticum collagenase depend chiefly on growth of the organism in complex culture media1,2. It is the purpose of this communication to describe a relatively simple, partially defined medium for the production of large quantities of highly active fermentation broths of Cl. histolyticum collagenase. The medium described appeared to facilitate the isolation and purification of collagenases which were essentially free of non-specific proteinases3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
MacLennan, J. D., Mandl, I., and Howes, E. L., J. Clin. Invest., 32, 1317 (1953).
Lytell, A. A., and Hewson, K., Proc. Soc. Exp. Biol. and Med., 74, 555 (1950).
Grant, N. A., and Alburn, H., Arch. Biochem. Biophys., 82, 245 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WARREN, G., GRAY, J. A Simplified Culture Medium for the Production of Collagenase. Nature 192, 755–756 (1961). https://doi.org/10.1038/192755a0
Issue Date:
DOI: https://doi.org/10.1038/192755a0
This article is cited by
-
Glycine fermentation by Clostridium histolyticum
Archives of Microbiology (1988)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
