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Inactivation of Naturally Occurring Variants of Tobacco Mosaic Virus with Nitrous Acid

Nature volume 195, pages 1029–1030 (1962)Cite this article

Abstract

ALTHOUGH there is general agreement that mutant strains of tobacco mosaic virus (TMV) may arise during oxidative de-animation of the ribonucleic acid by nitrous acid, this view has been held without conclusive evidence eliminating selection as a possible cause for the appearance of new strains. Soon after Gierer and Mundry1 announced the results of their experiments in which the mutagenesis of nitrous acid was implied, Bawden2 pointed out that their results did not, in fact, exclude the possibility of selection, and despite Mundry's counter-claims3, the issue has remained unsettled.

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References

  1. Gierer, A., and Mundry, K. W., Nature, 182, 1457 (1958). Mundry, K. W., and Gierer, A., Z. Verebungslehre, 89, 614 (1959).

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  2. Bawden, F. C., Nature, 184, 27 (1959).

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  3. Mundry, K. W., Virology, 9, 122 (1959).

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  4. Mundry, K. W., Z. Verebungslehre, 88, 115 (1957). Siegel, A., Virology, 8, 470 (1959). Wu, J. H., and Rappaport, I., ibid., 14, 259 (1961).

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  5. Rappaport, I., and Wu, J. H., Virology (in the press).

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Author notes

  1. IRVING RAPPAPORT

    Present address: La Rabida Institute, University of Chicago,

Authors and Affiliations

  1. Department of Botany, University of California, Los Angeles, 24

    IRVING RAPPAPORT & S. G. WILDMAN

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  1. IRVING RAPPAPORT
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  2. S. G. WILDMAN
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RAPPAPORT, I., WILDMAN, S. Inactivation of Naturally Occurring Variants of Tobacco Mosaic Virus with Nitrous Acid. Nature 195, 1029–1030 (1962). https://doi.org/10.1038/1951029a0

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