Abstract
DURING the course of work on the metabolism of synthetic œstrogenic compounds1 undertaken at this Institute, attention has been directed to the methyl ethers of some of the synthetic œstrogenic phenols. Preliminary experiments have been carried out on 4: 4′-dimethoxy diphenylether and 4-methoxy diphenyl; 4: 4′-dihydroxy diphenylether having been shown to produce full œstrous response when injected at a dose of 100 mgm. into ovariectomized rats, and 4-hydroxy diphenyl shown to have no oelig;strogenic activity at a dose of 100 mgm.2
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References
Stroud, S. W., J. Endocrin., 1, No. 2, 201 (1939); 2, No. 1, 55 (1940).
Dodds, E. C., and Lawson, W., Proc. Roy. Soc., B, 125, 222 (1938).
Westerfeld, W. W., Biochem. J., 34, 51 (1940).
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STROUD, S. Evidence of Demethylation in the Animal Body. Nature 146, 166 (1940). https://doi.org/10.1038/146166a0
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DOI: https://doi.org/10.1038/146166a0
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