To the editor:
In their recent article1, Ambati and colleagues present important data that provides insight into cell involvement in age-related macular degeneration (AMD). However, they erroneously state that there is “no animal model of drusen deposition or spontaneously occurring CNV [choroidal neovascularization] resembling that seen in patients with AMD.” Jackson Laboratories (Bar Harbor, Maine, USA) has a strain of mouse (C57BLKS-Bst/J) in which, “after seven months of age, 19% of heterozygotes have focal, nonrhegmatogenous, retinal detachment accompanied by subretinal neovascularization.” These symptoms of this strain were originally reported by Smith et al.2. Although Ambati et al. present an exciting finding of a new model for AMD, it would benefit the readers to be aware that there is at least another model of CNV that may also suit their research interests.
See Reply to “Mouse models of visual deficits” by Ambati et al.
References
Ambati, J. et al. Nat. Med. 9, 1390–1397 (2003).
Smith, R.S. et al. Proc. Natl. Acad. Sci. USA 97, 2191–2195 (2000).
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Sengupta, N., Caballero, S. Mouse models of visual deficits. Nat Med 10, 663 (2004). https://doi.org/10.1038/nm0704-663a
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DOI: https://doi.org/10.1038/nm0704-663a
