Why are humans particularly susceptible to HIV-1, whereas our monkey cousins are impervious to the virus? Part of the answer may lie with the virus' interaction with a cellular system of defense (pages 1138–1143).
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Renee Lucas
References
Towers, G.J. et al. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat. Med. 9, 1138–1143 (2003).
Goff, S.P. Operating under a Gag order: a block against incoming virus by the Fv1 gene. Cell 86, 691–693 (1996).
Towers, G. et al. A conserved mechanism of retrovirus restriction. Proc. Natl. Acad. Sci. USA 97, 12295–12299 (2000).
Cowan, S. et al. Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism. Proc. Natl. Acad. Sci. USA 99, 11914–11919 (2002).
Besnier, C., Takeuchi, Y. & Towers, G. Restriction of lentivirus in monkeys. Proc. Natl. Acad. Sci. USA 99, 11920–11925 (2002).
Münk, C., Brandt, S.M., Lucero, G. & Landau, N.R. A dominant block to HIV-1 replication at reverse transcription in simian cells. Proc. Natl. Acad. Sci. USA 99, 13843–13848 (2002).
Luban, J. et al. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73, 1067–1078 (1993).
Braaten, D., Franke, E.K. & Luban, J. Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J. Virol. 70, 3551–3560 (1996).
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Cullen, B. HIV-1 infection: fooling the gatekeeper. Nat Med 9, 1112–1113 (2003). https://doi.org/10.1038/nm0903-1112
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DOI: https://doi.org/10.1038/nm0903-1112
