Recent studies suggest that the Spt16 protein of FACT shuttles H2A–H2B dimers off and on nucleosomes during transcription elongation. By restoring nucleosomes after passage of RNA polymerase II, Spt16 and Spt6 prevent transcription from cryptic promoters in coding regions that would otherwise be expressed in the absence of histones.
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Carrozza, M., Kusch, T. & Workman, J. Repairing nucleosomes during transcription. Nat Struct Mol Biol 10, 879–880 (2003). https://doi.org/10.1038/nsb1103-879
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DOI: https://doi.org/10.1038/nsb1103-879
