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A fork in the road for microRNAs

Small RNAs can silence target genes by a variety of pathways and mechanisms. Specific microRNAs have now been shown to partition into distinct effector complexes, which may in turn affect their silencing output.

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Figure 1: MicroRNA sorting into Ago1 RISC and Ago2 RISC in Drosophila.

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Bellare, P., Sontheimer, E. A fork in the road for microRNAs. Nat Struct Mol Biol 14, 684–686 (2007). https://doi.org/10.1038/nsmb0807-684

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