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chapter 10 Enzymology of the Polyenes Pimaricin and Candicidin Biosynthesis
2009, Methods in EnzymologyCitation Excerpt :Characterization of pimaricin production in phoP-disrupted mutants and in phoR-phoP deletion mutants revealed that both mutants showed reduced sensitivity to phosphate control and an important increase in antifungal production (up to 80%) (Mendes et al., 2007b). Transcriptional control by phosphate of genes involved in polyene macrolide antibiotic biosynthesis has also been reported for candicidin (Asturias et al., 1990), suggesting that production of other polyenes might be increased by manipulation of this regulatory locus. The presence of γ-butyrolactones in different species of Streptomyces and their role in triggering secondary metabolite biosynthesis is well documented (Horinouchi and Beppu, 1992).
Polyenic Antibiotics and Other Antifungal Compounds Produced by Hemolytic Streptomyces Species
2022, International Journal of Molecular SciencesRegulation of secondary metabolites of actinobacteria
2017, Biology and Biotechnology of Actinobacteria
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