Biochimica et Biophysica Acta (BBA) - General Subjects
Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes
References (28)
- et al.
FEBS Lett.
(1979) - et al.
Biochim. Biophys. Acta
(1979) - et al.
Biochim. Biophys. Acta
(1983) - et al.
Biochem. Pharmacol.
(1985) - et al.
Biochim. Biophys. Acta
(1982) - et al.
Biochim. Biophys. Acta
(1984) - et al.
Inorg. Chim. Acta
(1982) Ann. Intern. Med.
(1979)- et al.
Semin. Hematol.
(1982)
N. Engl. J. Med.
Clin. Sci. Mol. Med.
Clin. Physiol. Biochem.
Cited by (78)
New mixed ligand oxidovanadium(IV) complexes: Solution behavior, protein interaction and cytotoxicity
2022, Journal of Inorganic BiochemistryCitation Excerpt :The chemistry of aroylhydrazones is of interest because of their facile keto-enol tautomerism and the availability of several donor sites which can coordinate to vanadium in +IV or +V oxidation states to form a stable complex [10–12,19,38,42,70–72]. The transition metal complexes ligated with hydrazones have attracted considerable attention for their wide range of biological activities such as antibacterial, antimalarial, antifungal and anticancer properties [10–20]. Again, ligands like 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen) have raised great interest not only because they can chelate several metal ions to form M–N bond(s), but also because they exhibit potent antitumor action [40,64,67,68,73–79], DNA binding and DNA-photocleavage activities [77–84].
Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro
2021, Journal of Biological ChemistryDesigning salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells
2018, Free Radical Biology and MedicineCitation Excerpt :Thus, chemical fine-tuning of the two process is important for designing novel Cu(II) ionophores for hitting redox Achilles heel of cancer cells. Salicylaldehyde isonicotinoyl hydrazone (SIH-1) (Scheme 1) is derived from a general group of pyridoxal isonicotinoyl hydrazone analogues which are originally designed as iron chelators to develop anticancer agents based on the fact that cancer cells have higher requirements for iron to maintain higher rates of proliferation than their normal counterparts [22–27]. This molecule is also able to chelate copper and has previously been identified as a monobasic tridentate (phenolic-oxygen, carbonyl-oxygen and azomethine-nitrogen) ligand to yield the Cu(II) complex with a metal-to-ligand ratio of 1:1 where the Cu(II) completes its four coordination by the attachment of one chlorine ion [28].
Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis
2016, TuberculosisCitation Excerpt :Additionally, we showed that the inhibition of both MtMetAP1s by 311 resulted in the effective inhibition of replicating and aged non-growing Mtb, further validating the potential of MtMetAP1s as chemotherapeutic targets and the promise of this active pyridoxal isonicotinoyl pharmacophore for the development of anti-infectives that have dual anti-TB and anti-HIV activity. The pyridoxal isonicotinoyl class [35] is an attractive pharmacophore that has been investigated extensively because of its multiple activity as molecular switches and metallo-assemblies [41]. Specifically, 311 has been of interest as an iron chealtor [35,38,44–46] with functionally diverse activity against targets for cancer, malaria and HIV [35–37,41,43–47].
Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells
2014, Free Radical Biology and Medicine