Elsevier

Peptides

Volume 9, Issue 2, March–April 1988, Pages 315-317
Peptides

Article
Effect of vasoactive intestinal peptide on dopaminergic system in the rat brain

https://doi.org/10.1016/0196-9781(88)90266-5Get rights and content

Abstract

The present study analyzed the effect of vasoactive intestinal peptide (VIP) on the content of dopamine (DA) and its main metabolite, DOPAC, in the rat brain. Intracerebroventricular administration of VIP increased the DA and DOPAC content, causing a dose-dependent increase in the DOPAC/DA ratio in various regions of the brain. The results suggest that VIP facilitates the DA metabolism in the brain.

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    Present address: US-Japan Biomedical Research Laboratories, Laboratory for Molecular Neuroendocrinology and Diabetes, Tulane University Hebert Center, Bldg. 30, Belle Chase, LA 70037.

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