Enzymatic biosynthesis of cyclosporin A and analogues
References (28)
- et al.
Isolation and amino acid sequence of cyclophilin
J Biol Chem
(1986) - et al.
Enzymatic synthesis of cyclosporin A
J Biol Chem
(1987) - et al.
Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described
J Biol Chem
(1990) - et al.
δ-(l-ga-Aminoadipyl)-l-cysteinyl-d-valine synthetase from Aspergillus nidulans. The first enzyme in penicillin biosynthesis is multifunctional peptide synthetase
J Biol Chem
(1989) - et al.
The cluster of penicillin biosynthetic genes: identification and characterization of the pcbAB gene encoding the α-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes
J Biol chem
(1990) - et al.
In vitro biosynthesis of [Thr2,Leu5,d-Hiv8,Leu10]cyclosporin, a cyclosporin-related peptolide with immunosuppressive activity by a multi-enzyme polypeptide
J Biol Chem
(1991) - et al.
Molecular weight of homogenous coli phages DNA's from density gradient sedimentation equilibrium
J Mol Biol
(1969) Editorial: cyclosporin and its future
Prog Allergy
(1986)
Neue Cyclosporine]aus Tolypocladium inflatum. Die Cyclosporine K-Z
Helv Chim Acta
(1987)
Cyclosporins — new analogues by precursor directed biosynthesis
J Antibiot
(1989)
Synthesis of cyclosporine. Total syntheses of ‘cyclosporin A’ and ‘cyclosporin H’, two fungal metabolites isolated from the species Tolypolcadium inflatum GAMS
Helv Chim Acta
(1984)
A study of the correlation between cyclophilin binding and in vitro immunosuppressive activity of cyclosporin A and analogues
Transplant Proc
(1988)
Cited by (21)
Biosynthesis of cyclosporins and other natural peptidyl prolyl cis/trans isomerase inhibitors
2015, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :The final transformation enzymes have not been identified yet; interestingly though, the CySyn biosynthetic cluster contains a cytochrome b2-like protein, a dehydrogenase and an aminotransferase [6], which make good candidate enzymes for the final transformations of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoyl-CoA into Bmt. As CySyn has no intrinsic racemase activity [12,57,59,62], the enzyme needs to be supplied with the non-proteinogenic amino acid d-alanine to start cyclosporin biosynthesis. An oligomeric alanine racemase from T. inflatum (strain 7939/45) was first reported by Hoffmann et al. [121].
An improved purification procedure for cyclosporin synthetase
2006, Protein Expression and Purification2 Biosynthesis and Mechanism of Action of Cyclosporins
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2017, Angewandte Chemie - International EditionTrifunctional Organocatalysts: Catalytic Proficiency by Cooperative Activation
2015, European Journal of Organic ChemistryPeptides: Chemistry and Biology: Second Edition
2009, Peptides: Chemistry and Biology: Second Edition
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