The response of the hypophysectomized cyprinodont, Fundulus heteroclitus, to replacement therapy with cortisol: Effects on blood serum and sodium-potassium activated adenosine triphosphatase in the gills, kidney, and intestinal mucosa

doi:10.1016/0016-6480(70)90036-5

General and Comparative Endocrinology

Volume 14, Issue 3, June 1970, Pages 524-534

https://doi.org/10.1016/0016-6480(70)90036-5 Get rights and content

Abstract

Regulation of the inorganic constituents of the serum is nearly perfect in hypophysectomized Fundulus heteroclitus maintained in salt water, although serum Cl is lower.

Chronic treatment with cortisol had no effect on serum Na or serum Ca; serum K and serum Cl decreased, serum inorganic PO₄ and serum Mg increased.

Na + K-ATPase activity increased in cortisol-treated fish in three organs that participate in osmoregulation: the gills, the kidneys (males only), and the intestinal mucosa. The increase in the gills can be correlated with a restoration of total Na exchange, previously reported by Mayer and Maetz (1967). The increased activity in the intestine, previously reported by Hirano et al. (1967) in Anguilla japonica, is presumably associated with the increased rate of Na turnover. Increased activity in the kidneys may reflect an increase in the glomerular filtration rate and (or) a restoration of renal Na retention.

Other effects of cortisol are: a decrease in body weight, an increase in the abundance of circulating erythrocytes, leukocytosis after a single injection or short treatment that is regulated after longer treatment, and an increase in the relative weight of the liver that may be associated with gluconeogenesis. Cortisol had no effect on the relative size of the regressed gonads in either sex.

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¹: Supported by a grant from the National Science Foundation (GB-5509 X).

²: Fellow of the National Kidney Foundation 1968–1970.

³: Special Research Fellow of the United States Public Health Service, 1968–1969.

⁴: Supported by grants from the National Institutes of Health (HE-00834, AM-5015, Research Career Award 4K06 AM 21578).

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The response of the hypophysectomized cyprinodont, Fundulus heteroclitus, to replacement therapy with cortisol: Effects on blood serum and sodium-potassium activated adenosine triphosphatase in the gills, kidney, and intestinal mucosa

Abstract

Gen. Comp. Endocrinol

Gen. Comp. Endocrinol

Gen. Comp. Endocrinol. Suppl

Gen. Comp. Endocrinol

Steroids

Gen. Comp. Endocrinol

Comp. Biochem. Physiol

Comp. Biochem. Physiol

Gen. Comp. Endocrinol

Gen. Comp. Endocrinol

Gen. Comp. Endocrinol

Steroids

Comp. Biochem. Physiol

Comp. Biochem. Physiol

Gen. Comp. Endocrinol

Gen. Comp. Endocrinol

The effect of steroid hormones on the development of the reproductive system of Salmo trutta L. when administered at the commencement of spermatogenetic activity in the testes

Riv. Biol

Bibliography on the steroid hormones of fishes

Publ. Staz. Zool. Napoli

The failure of hypophysectomized Fundulus heteroclitus to survive in fresh water

Biol. Bull

L'anguille européene (Anguilla anguilla L.). Les bases physiologiques de sa migration

Ann. Inst. Océanogr

Regulation and distribution of plasma calcium and inorganic phosphate in the European eel (Anguilla anguilla L.)

J. Endocrinol

Studies on the experimental alteration of water and electrolyte composition of the eel (Anguilla anguilla L.)

J. Endocrinol

Pituitary and adrenocortical factors in the control of the water and electrolyte composition of the freshwater European eel (Anguilla anguilla L.)

J. Endocrinol

Sodium- and potassium-activated adenosine triphosphatase of gills: Role in adaptation of teleosts to salt water

Science

Sodium- and potassium-activated adenosine triphosphatase in kidneys of Fundulus heteroclitus adapted to fresh and salt water

Yale J. Biol. Med

Endocrine influences on the net extrarenal fluxes of sodium and potassium in the European eel (Anguilla anguilla L.)

J. Endocrinol