Androgen-responsive expression and mitogenic activity of schwannoma-derived growth factor on an androgen-dependent Shionogi mouse mammary carcinoma cell line

https://doi.org/10.1016/S0006-291X(05)80961-1Get rights and content

Summary

We report here, using the androgen-dependent SC2G cell line derived from Shionogi mouse mammary carcinoma SC115, that cDNA encoding mouse homologue of the rat schwannoma-derived growth factor (SDGF) was isolated and its protein product was identified to be an autocrine growth factor which is expressed in response to androgen in this hormone-dependent cell line. The androgen-independent SC1G cells derived from SC115 were shown to express SDGF even in the absence of androgen, while Northern analysis probed with mouse mammary tumor virus (MMTV) DNA showed that the androgen inducible transcriptional machinery remains functional in this hormone independent cell line.

References (29)

  • DerynckR. et al.

    Cell

    (1984)
  • MassaguéJ.

    J. Biol. Chem.

    (1990)
  • WongS.T. et al.

    Cell

    (1989)
  • BrachmannR. et al.

    Cell

    (1989)
  • MineshitaT. et al.

    Steroids

    (1964)
  • MineshitaT. et al.

    Cancer Res.

    (1965)
  • MatsumotoK. et al.
  • BruchovskyN. et al.

    Cancer Res.

    (1985)
  • NonomuraN. et al.

    Cancer Res.

    (1988)
  • FuruyaY. et al.

    Cancer Res.

    (1990)
  • Yamaguchi,T., Kawamoto,K., Uchida,N., Uchida,K. and Watanabe,S. In Vitro Cell.Dev.Biol., in...
  • Kawamoto,K., Yamaguchi,T., Watanabe,S. and Uchida,K. Biochim.Biophys.Acta, in...
  • KimuraH. et al.

    Nature

    (1990)
  • AruffoA. et al.
  • Cited by (9)

    View all citing articles on Scopus
    View full text