Kinetic resolution of racemic carboxylic acids with homochiral alcohols and dicyclohexylcarbodiimide

doi:10.1016/S0957-4166(00)80527-3

Tetrahedron: Asymmetry

Volume 2, Issue 2, 1991, Pages 101-104

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Abstract

Racemic carboxylic acids have been kinetically resolved by means of homochiral alcohols using the DCC-esterification methodology. The best results were obtained with commercially available homochiral 1-(4-pyridyl)ethanol: <60% e.e. for enantiomerically enriched acids and <76% d.e. for diastereomerically enriched esters.

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Kinetic resolution of racemic carboxylic acids with homochiral alcohols and dicyclohexylcarbodiimide

Abstract

Tetrahedron: Asymmetry

Tetrahedron Lett.

Tetrahedron Lett.