Peptides—XXXXIII: Synthesis of the 94–104 fragment of a lysozyme analogue

doi:10.1016/S0040-4020(01)98917-3

Tetrahedron

Volume 37, Issue 17, 1981, Pages 3025-3029

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Abstract

The synthesis of the (94–104) fragment of a lysozyme analogue is reported by union of the protected (94–98) and (99–104) subfragments using the N-hydroxysuccinimide active ester of the (94–98) fragment. This choice of coupling method was made on the basis of a study employing a range of established methods using the criteria of yield and minimum racemisation.

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Cited by (1)

Peptides-XXXXVI. Studies in the synthesis of an analogue of hen egg white lysozyme
1981, Tetrahedron
The previously synthesised (1–37), (38–75), (76–93), (94–104), (105–117) and (118–129) fragments of the analogue were combined making extensive use of the DCCI/HONSu method. The final coupling involved the (1–75) and (76–129) sub-fragments. Aggregation of the latter fragment caused problems in purification by routine gel filtration methods employing Enzacryl K2 or Sephadex LH60. The fully protected (1–129) product was partially purified by washing, then deprotectcd and purified by gel filtration and ion exchange chromatography. Satisfactory removal of the acetamidomethyl group used for cysteine protection could not be achieved.

¹: Deceased June 1978.

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Peptides—XXXXIII: Synthesis of the 94–104 fragment of a lysozyme analogue

Abstract

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