Elsevier

FEBS Letters

Volume 219, Issue 2, 27 July 1987, Pages 279-282
FEBS Letters

Role of Mg2+ in the ribozyme system

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Abstract

Recently, several kinds of catalytic activities have been identified from L-19 IVS RNA or ‘ribozyme’. In the catalytic process of ribozyme, Mg2+ is required. We investigated the role of Mg2+ by molecular orbital calculation. Based on the results of the calculation, a model for the self-splicing reaction was constructed.

Keywords

Ribozyme
Mg2+
Ab initio molecular orbital calculation

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