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Indirect detection in reversed-phase liquid chromatography: Ion-pair retention models for anionic analytes and mobile phase components on polystyrene polymers using an alkaline mobile phase

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Summary

Retention models for anionic analytes and mobile phase compounds in reversed-phase ion-pair chromatographic systems have been studied. The solid phase was a polystyrene-divinylbenzene copolymer. The analytes were mono- and divalent anions monitored by indirect detection technique. The mobile phase was highly alkaline and contained a detectable anion, sulfanilic acid.

Expressions for the ion-pair retention of solutes and mobile phase components have been developed assuming Langmuir distribution of ion-pairs to a solid phase with one kind of binding site. The validity of the expressions and the origin of system peaks have been confirmed by determination of distribution constants using linear regression.

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Author notes

  1. E. Arvidsson

    Present address: Department of Analytical Chemistry, AB Hässle, S-431 83, Mölndal, Sweden

Authors and Affiliations

  1. Dept. of Analytical Chemistry, Institute of Pharmacy, University of Liège, rue Fusch 5, 4000, Liège, Belgium

    J. Crommen

  2. Dept. of Analytical Pharmaceutical Chemistry, Uppsala University, Biochemical Centre, P.O. Box 574, S-75123, Uppsala, Sweden

    E. Arvidsson, G. Schill & D. Westerlund

Authors
  1. E. Arvidsson
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  2. J. Crommen
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  3. G. Schill
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  4. D. Westerlund
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Arvidsson, E., Crommen, J., Schill, G. et al. Indirect detection in reversed-phase liquid chromatography: Ion-pair retention models for anionic analytes and mobile phase components on polystyrene polymers using an alkaline mobile phase. Chromatographia 26, 45–52 (1988). https://doi.org/10.1007/BF02268123

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  • DOI: https://doi.org/10.1007/BF02268123

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