Skip to main content
SpringerLink
Log in

Acrylic acid copolymer nanoparticles for drug delivery. Part II: Characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants

  • Original Contributions
  • Published:
Colloid and Polymer Science Aims and scope Submit manuscript

Abstract

Copolymer nanoparticles of acrylic acid, acrylic amide, acrylic butylester, and methacrylic methylester with increasing content of acrylic acid were produced and surface-modified by adsorption of nonionic (Poloxamer 407, Poloxamine 908, Antarox CO 990) and ionic (Gafac RE 960) surfactants. The coated particles were characterized with regard to parameters relevant for the in vivo organ distribution: coating layer thickness, charge-reducing effect of the coating layer and surface hydrophobicity. Gafac was found to form highly charged surface layers leading to recognition by the reticuloendothelial system (RES). The hydrophobicity of the coating layers decreased with increasing thickness. The thickest coating layers were found on the most hydrophobic particles possessing least content of acrylic acid (1.9%). These particles coated with the nonionics were regarded as sufficiently hydrophilic to potentially reduce the uptake by the RES in vivo. The properties of coating layers can therefore be optimized by variation of the monomer ratios in copolymers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Davis SS, Douglas S, Illum L, Jones PDE, Mak E, Müller RH (1986) In: Gregoriadis G, Senior J and Poste G (eds.) Targeting of colloidal carriers and the role of surface properties in targeting of drugs with synthetic systems. Plenum Press, New York, 123–146

    Google Scholar 

  2. Müller RH, Blunk T (1989) Arch Pharm 322:698

    Google Scholar 

  3. Lukowski G, Müller RH, Müller BW, Dittgen M (1991) Acrylic acid copolymer nanoparticles for drug delivery I: Characterization of the surface properties relevant for the in vivo organ distribution (submitted to Int J Pharm)

  4. Illum L, Davis SS, Müller RH, Mak E, West P (1987) Life Sci 40:367–374

    Google Scholar 

  5. Illum L, Davis SS (1983) J Pharm Sci 72:1086–1089

    Google Scholar 

  6. Illum L, Davis SS (1984) FEBS Lett 167:79

    Google Scholar 

  7. Lherm C, Müller RH, Blunk T, Perie M (1988) Arch Pharm 321:682

    Google Scholar 

  8. Rawlins DA, Kayes JB (1983) Int J Pharm 13:145–185

    Google Scholar 

  9. Law SL, Kayes JB (1983) Int J Pharm 15:251–260

    Google Scholar 

  10. Kronberg B, Käll L, Stenius P (1981) J Dispersion Science and Technology 2:215–232

    Google Scholar 

  11. Kronberg B, Käll L, Stenius P (1983) J Colloid Interf Sci 96:55–68

    Google Scholar 

  12. Kronberg B, Stenius P, Igeborn G (1984) J Colloid Interf Sci 102:418–420

    Google Scholar 

  13. Dittgen M, zosel B, Vogel B, Heimann T (1991) Influence of the components of polyacrylic batches on their potential as carriers in drug targeting (submitted to Drug Dev Ind Pharm)

  14. Cummins HS, Pike ER (1973) Photon Correlation and Light Beating Spectroscopy. NATO Advanced Study Institutes Series B, Plenum Press, New York

    Google Scholar 

  15. Cummins HS, Pike ER (1976) Photon Correlation Spectroscopy and Velocimetry NATO Advanced Studies Institutes Series B. Plenum Press, New York

    Google Scholar 

  16. Stampa B, Lucks JS, Müller BW, Müller RH (1991) J Coll Interf Sci 143:188–194

    Google Scholar 

  17. James AM (1979) Electrophoresis of particles in suspensions. In: Good RJ, Stromberg RR (eds.) Surface and Colloid Science Vol 11. Plenum Press, New York, pp. 121–127

    Google Scholar 

  18. Carstensen H, Müller BW, Müller RH (1991) Int J Pharm 67:29–37

    Google Scholar 

  19. Wallis, KH, Müller RH (1990) Arch Pharm 323:766

    Google Scholar 

  20. Müller RH (1991) Colloidal carriers for controlled drug delivery and targeting — modification, characterization and in vivo distribution, Wissenschaftliche Verlagsgesellschaft, CRC Press, Stuttgart/Boca Raton

    Google Scholar 

  21. Cosgrove T, Crowley TL, Vincent B (1981) The configuration of adsorbed polymers at the solid-solution interface. Faraday Symp Chem Soc 16:101–108

    Google Scholar 

  22. Cosgrove T, Crowley TL, Vincent B (1983) An experimental study of conformations at the solid/solution interface. Adsorption Solution Symposium, pp 287–297

  23. Müller RH, Blunk T, Koosha F (1988) Arch Pharm 321:34

    Google Scholar 

Download references

Author information

Author notes

  1. M. Dittgen

    Present address: Department of Pharmaceutics, E.-M.-Arndt-University, Jahnstr. 17, O-2200, Greifswald, FRG

  2. R. H. Müller

    Present address: Department of Pharmaceutics and Biopharmaceutics, Christian-Albrechts-University, Gutenbergstr 76-78, 2300, Kiel, FRG

Authors and Affiliations

  1. Department of Pharmaceutics, E.-M.-Arndt-University, Jahnstr. 17, O-2200, Greifswald, FRG

    G. Lukowski

  2. Department of Pharmaceutics and Biopharmaceutics, Christian-Albrechts-University, Gutenbergstr 76-78, 2300, Kiel, FRG

    B. W. Müller

Authors
  1. G. Lukowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. H. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. W. Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Dittgen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lukowski, G., Müller, R.H., Müller, B.W. et al. Acrylic acid copolymer nanoparticles for drug delivery. Part II: Characterization of nanoparticles surface-modified by adsorption of ethoxylated surfactants. Colloid Polym Sci 271, 100–105 (1993). https://doi.org/10.1007/BF00652310

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00652310

Key words

Search

Navigation