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On the hypothetical protein F154 of the TTV1 virus/Thermoproteus Tenax. Part II: Synthesis of the trieicosapeptide, corresponding to the protein sequence 79–101

Zur Hypothese eines TTV1 Virus/Thermoproteus tenax F154-Proteins. Teil II: Synthese des Protein-fragments 79–101

  • Organische Chemie Und Biochemie
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Summary

For the identification of a protein predicted by DNA sequence analysis of the TTV1 virus from the archaebacteriumThermoproteus tenax, the trieicosapeptide H-Thr-Pro-Thr-Pro-Thr-Pro-Thr-Tyr-Asp-Ile-Thr-Tyr-Val-Val-Phe-Asp-Val-Thr-Pro-Ser-Pro-Thr-Pro-OH, corresponding to the protein fragment 79–101, was prepared by conventional methods of peptide synthesis. This sequence portion may possibly represent a suitable protein specific immunepitope.

Zusammenfassung

Für den Nachweis der Expression des Proteins F154 — nach einer Sequenzanalyse des Genoms des TTV1 Virus im ArchaebakteriumThermoproteus tenax postuliert — wurde das Peptid H-Thr-Pro-Thr-Pro-Thr-Pro-Thr-Tyr-Asp-Ile-Thr-Tyr-Val-Val-Phe-Asp-Val-Thr-Pro-Ser-Pro-Thr-Pro-OH (Proteinfragment 79–101) mit Hilfe konventioneller Peptidsynthese hergestellt. Diese Peptidsequenz sollte ein geeignetes proteinspezifisches Immunepitop darstellen.

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References

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Author notes

  1. Daniel Krois

    Present address: Institut für Organische Chemie, Universität Wien, A-1090, Wien, Austria

  2. Mario Simonetti

    Present address: Centro di Studi sui Biopolimeri, Università di Padova, I-35131, Padova, Italy

Authors and Affiliations

  1. Abteilung für Peptidchemie, Max-Planck-Institut für Biochemie, D-8033, Martinsried, Federal Republic of Germany

    Daniel Krois, Mario Simonetti & Erich Wünsch

Authors
  1. Daniel Krois
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  2. Mario Simonetti
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  3. Erich Wünsch
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Krois, D., Simonetti, M. & Wünsch, E. On the hypothetical protein F154 of the TTV1 virus/Thermoproteus Tenax. Part II: Synthesis of the trieicosapeptide, corresponding to the protein sequence 79–101. Monatsh Chem 120, 1029–1041 (1989). https://doi.org/10.1007/BF00808775

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  • DOI: https://doi.org/10.1007/BF00808775

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