Abstract
The cerebellar mouse mutation stumbler (stu) was mapped to proximal Chromosome (Chr) 2 with a recently developed polymerase chain reaction assay for endogenous retroviruses that vary between mouse strains. The stu locus resides between the markers D2Mit5 and D2Mit7. A number of developmentally or neurologically relevant candidate genes map in this region, including Bmi1, Dbh, Grin1, Notch1, Pax8, Rxra, and Spna2. Knowing the chromosomal localization of stu should simplify maintenance of the stumbler mouse stock and also enable analysis of the cerebellar defect in presymptomatic individuals.
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Birkenmeier, C.S., McFarland-Starr, E.C., Barker, J.E. (1988). Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man. Proc. Natl. Acad. Sci. USA 85, 8121–8125.
Caddy, K.W.T., Sidman, R.L. (1981). Purkinje cells and granule cells in the cerebellum of the stumbler mutant mouse. Dev. Brain Res. 1, 221–236.
Caddy, K.W.T., Sidman, R.L., Eicher, E.M. (1981). Stumbler, a new mutant mouse with cerebellar disease. Brain Res. 208, 251–255.
Cagan, R.L., Ready, D.F. (1989). Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 3, 1099–1112.
Collins, C., Duff, C., Duncan, A.M.V., Planells-Cases, R., Sun, W., Norremolle, A., Michaelis, E., Montal, M., Worton, R., Hayden, M.R. (1993). Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively. Genomics 17, 237–239.
Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Nadeau, J.H., Eppig, J.T., Maltais, L.J., Miller, J.C., Dietrich, W.F., Steen, R.G., Lincoln, S.E., Weaver, A., Joyce, D.C., Merchant, M., Wessel, M., Katz, H., Stein, L.D., Reeve, M.P., Daly, M.J., Dredge, R.D., Marquis, A., Goodman, N., Lander, E.S. (1993). Genome maps IV. Science 262, 67–82.
Cox, R.D., Copeland, N.G., Jenkins, N.A., Lehrach, H. (1991). Interspersed repetitive element polymerase chain reaction product mapping using a mouse interspecific backcross. Genomics 10, 375–384.
Dietrich, W.F., Katz, H., Lincoln, S.E., Shin, H.-S., Freidman, J., Dracopoli, N., Lander, E.S. (1992). A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131, 423–447.
Drivas, G., Massey, R., Chang, H.-Y., Rush, M.G., D'Eustachio, P. (1991). Ras-like genes and gene families in the mouse. Mamm. Genome 1, 112–117.
Franco Del Amo, F., Gendron-Marguire, M., Swiatek, P.J., Jenkins, N.A., Copeland, N.G., Gridley T. (1993). Cloning, analysis and chromosomal localization of notch-1, a mouse homolog of Drosophila notch. Genomics 15, 259–264.
Frankel, W.N., Stoye, J.P., Taylor, B.A., Coffin, J.M. (1990). A genetic linkage map of endogenous murine leukemia proviruses. Genetics 124, 221–236.
Greenspan, R. (1990). The Notch gene, adhesion, and developmental fate in the Drosophila embryo. New Biol. 2, 595–600.
Hoopes, C.W., Taketo, M., Ozato, K., Liu, Q., Howard, T.A., Linney, E., Seldin, M.F. (1992). Mapping the mouse Rxr loci encoding nuclear retinoid X receptors Rxr-alpha, Rxr-beta, and Rxr-gamma. Genomics 14, 611–617.
Johnson, K.R., Cook, S.A., Ward-Bailey, P., Bustin, M., Davisson, M.T. (1993). Identification and genetic mapping of the murine gene and 20 related sequences encoding chromosomal protein HMG-17. Mamm. Genome 4, 83–89.
Kaushik, N., Stoye, J.P. (1994). Intracisternal A-type particles as genetic markers: detection by repeat element viral element amplified locus-PCR. Mamm. Genome, submitted for publication.
Lander, E.S., Green, P., Abrahamson, J., Barlow, A., Daly, M.J., Lincoln, S.E., Newberg, L. (1987). MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1, 174–181.
Manly, K.F., Elliot, R.W. (1991). RI manager, a microcomputer program for analysis of data from recombinant inbred strains. Mamm. Genome 1, 123–127.
Pilz, A., Moseley, H., Peters, J., Abbott, C. (1992). Comparative mapping of mouse Chromosome 2 and human Chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse Chromosome 2. Genomics 12, 715–771.
Pilz, A.J., Povey, S., Gruss, P., Abbott, C.M. (1993). Mapping of the human homologs of the murine paired-box-containing genes. Mamm. Genome 4, 78–82.
Plachov, D., Chowdhury, K., Walther, C., Simon, D., Guénet, J.-L., Gruss, P. (1990). Pax-8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110, 643–651.
Reaume, A.G., Conlon, R.A., Zirngibl R., Yamaguchi, T.P., Rossant, J. (1992). Expression analysis of a notch homologue in the mouse embryo. Dev. Biol. 154, 377–387.
Rowe, L.B., Nadeau, J.H., Turner, R., Frankel, W.N., Letts, V.A., Eppig, J.T., Ko, M.S.H., Thurston, S.J., Birkenmeier, E.H. (1994). Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome, in press.
Siracusa, L.D., Mercer, J.A., Banskin, A.R., Ben-Neriah, Y., Deboule, D., Hastie, N.D., Jenkins, N.A., Copeland, N.G. (1990). A molecular linkage map of mouse Chromosome 2. Genomics 6, 491–504.
Siracusa, L.D., Jenkins, N.A., Copeland, N.G. (1991). Identification and applications of repetitive probes for gene mapping in the mouse. Genetics 127, 169–179.
Stoye, J.P., Coffin, J.M. (1988). Polymorphism of murine endogenous proviruses revealed by using virus class-specific oligonucleotide probes. J. Virol. 62, 168–175.
Taylor, B.A., Rowe, L. (1989). A mouse linkage testing stock prossessing multiple copies of the endogenous ecotropic murine leukemia virus genome. Genomics 5, 221–232.
van der Lugt, N.M.T., Domen, J., Linders, K., van Room, M., Robanus-Maandag, E., te Riele, H., van der Valk, M., Deschamps, J., Sofroniew, M., van Lohuizen, M., Berns, A. (1994). Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev. 8, 757–769.
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Frankel, W.N., Sweet, H.O. & Davisson, M.T. The stumbler mutation maps to proximal mouse Chromosome 2. Mammalian Genome 5, 659–662 (1994). https://doi.org/10.1007/BF00426071
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DOI: https://doi.org/10.1007/BF00426071