Abstract.
Mouse cDNA sequences encoding α, β, and γ adducins were cloned from a mouse reticulocyte cDNA library. The purified clones contain alternatively spliced exons from all three adducin genes. In the case of α and β, the inclusion of the alternatively spliced exons results in truncated polypeptide isoforms (called α-2 and β-2). The mouse predicted amino acid sequences are compared with published rat and human sequences. For completion of this comparison, cDNA encoding the rat β-1 carboxy terminus was cloned by PCR. The carboxy terminal region containing MARCKS homology, calmodulin-binding region-2, and spectrin-actin-binding site, is conserved among α-1, β-1, and γ-1 isoforms in mouse, rat, and humans. We also report here the localization of the gene encoding γ adducin (Add3) to murine Chr 19, in a region that shows conserved synteny with human Chr 10.
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Received: 1 June 1999 / Accepted: 25 August 1999
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Suriyapperuma, S., Lozovatsky, L., Ciciotte, S. et al. The mouse adducin gene family: alternative splicing and chromosomal localization. Incorporating Mouse Genome 11, 16–23 (2000). https://doi.org/10.1007/s003350010004
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DOI: https://doi.org/10.1007/s003350010004