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Mouse X chromosome

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Conclusion

Overall, the probe map fromDXWas70 toAmg encompasses 72 cM and includes 103 loci. Eight of these have been designated reference loci (see Table 2 and previous section) on account of their wide usage that would enable the cross reference of independent maps created in different laboratories. Reference loci are to be readily available and easily used probes for Southern hybridization. By and large, they will be STSs, regeneratable by PCR, and correspond to a known gene. In addition, on the mouse X Chr, there is a reference locus from each of the known conserved linkage groups found between the mouse and human X Chrs. All the loci, barDXWas31, represent conserved sequences.

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References

  • Amar, L.C., Arnaud, D., Cambrou, J., Guenet J.L., and Avner, P.R.: Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross.EMBO J 4: 3695–3700, 1985.

    Google Scholar 

  • Amar, L.C., Dandalo, L., Hanauer, A., Ryder-Cook, A., Arnaud, D., Mandel, J.L., and Avner, P.: Conservation and reorganisation of loci on the mammalian X chromosome: A molecular framework for the identification of homologous subchromosomal regions in man and mouse.Genomics 2: 220–230, 1988.

    Google Scholar 

  • Avner, P., Amar, L., Arnaud, D., Hanauer, A., and Cambrou, J.: Detailed ordering of markers localising to the Xq26-Xqter region of the human chromosome by the use of an interspecificMus spretus mouse cross.Proc Natl Acad Sci USA 84: 1629–1633, 1987a.

    Google Scholar 

  • Avner, P., Arnaud, D., Amar, L., Cambrou, J., Winking H., and Russell, L.B.: Characterisation of a panel of somatic cell hybrids for regional mapping of the mouse X chromosome.Proc Natl Acad Sci USA 84: 5330–5334, 1987b.

    Google Scholar 

  • Avner, P., Bucan, M., Arnaud, D., Lehrach, H., and Rapp, U.: A-raf oncogene localises on mouse X chromosome to region some 10–17 centimorgans proximal to hypoxanthine phosphoribosyl-transferase gene.Som Cell Mol Genet 13: 267–272, 1987c.

    Google Scholar 

  • Avner, P., Amar, L., Dandalo, L., and Guénet, J.L.: Genetic analysis of the mouse using interspecific crosses.Trends Genet 4: 18–23, 1988.

    Google Scholar 

  • Barnard, P., Derry, J.M.J., Ryder-Cook, A.S., Zander, N.F., and Kilimann, M.W.: Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.Cytogenet Cell Genet 53: 91–94, 1990.

    Google Scholar 

  • Brockdorff, N., Cross, G.S., Cavanna, J.S., Fisher, E.M.C., Lyon, M.F., Davies K.E., and Brown, S.D.M.: The mapping of a cDNA from the human X-linked Duchenne muscular dystrophy gene to the mouse X chromosome.Nature 328: 166–168, 1987a.

    Google Scholar 

  • Brockdorff, N., Fisher, E.M.C., Cavanna, J.S., Lyon, M.F., and Brown, S.D.M.: Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses.EMBO J 6: 3291–3297, 1987b.

    Google Scholar 

  • Brockdorff, N., Fisher, E.M.C., Orkin, S.H., Lyon, M.F., and Brown, S.D.M.: Localisation of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome.Cytogenet Cell Genet 48: 124–125, 1988.

    Google Scholar 

  • Brockdorff, N., Amar, L.C., and Brown, S.D.M.: Pulse-field linkage of theP3, G6pd andCf-8 genes on the mouse X chromosome: Demonstration of synteny at the physical level.Nucl Acid Res 17: 1315–1326, 1989.

    Google Scholar 

  • Brockdorff, N., Montague, M., Smith, S., and Rastan, S.: Construction and analysis of the linking libraries from the mouse X chromosome.Genomics 7: 573–578, 1990.

    Google Scholar 

  • Brockdorff, N., Kay, G., Smith, S., Keer, J.T., Hamvas, R.M.J., Brown, S.D.M., and Rastan, S.: High density molecular map of the central span of the mouse X chromosome.Genomics 10: 17–22, 1991.

    Google Scholar 

  • Brown, R.M., Dahl, H-H.M., and Brown, G.K.: An homologous locus to the human X-linked pyruvate dehydrogenase E1α subunit gene is located at the distal end of the mouse X chromosome.Cytogenet Cell Genet 51: 970, 1989a.

    Google Scholar 

  • Brown, R.M., Dahl, H-H.M., and Brown, G.K.: X-chromosome localisation of the functional gene for the E1α subunit of the human pyruvate dehydrogenase complex.Genomics 4: 174–181, 1989b.

    Google Scholar 

  • Buckle, V.J., Fujita, N., Ryder-Cook, A.S., Derry, J.M.J., Barnard, P.J., Lebo, R.V., Schofield, P.R., Seeburg, P.H., Bateson, A.N., Darlison, M.G., and Barnard, E.A.: Chromosomal localisation of GABAA receptor subunit genes: relationship to human genetic disease.Neuron 3: 647–654, 1989.

    Google Scholar 

  • Cattanach, B.M., Raspberry, C., Evans, E.P., Dandalo, L., Simmler, M.C., and Avner, P.: Genetic and molecular evidence of a X chromosome deletion spanning the tabby (Ta) and testicular feminisation (Tfm) loci in the mouse.Cytogenet Cell Genet 56: 137–143, 1991.

    Google Scholar 

  • Cavanna, J.S., Coulton, G., Morgan, J., Brockdorff, N., Forrest, S.M., Davies, K.E., and Brown, S.D.M.: Molecular and genetic mapping of the mousemdx locus.Genomics 3: 337–341, 1988.

    Google Scholar 

  • Chamberlain, J.S., Grant, S.G., Reeves, A.A., Mullins, L.J., Stephenson, D.A., Hoffman, E.P., Monaco, A.P., Kunkel, L.M., Caskey, C.T., and Chapman, V.M.: Regional localisation of the murine Duchenne muscular dystrophy gene on the mouse X chromosome.Somat Cell Mol Genet 13: 671–678, 1987.

    Google Scholar 

  • Chapman, V.M., Keitz, B.T., Stephenson, D.A., Mullins, L.J., Moos, M., and Schachner, M.: Linkage of a gene for a neural cell adhesion molecule, L1 (CamL1) to theRsvp region of the mouse X chromosome.Genomics 8: 113–118, 1990.

    Google Scholar 

  • Chapman, V.M., Keitz, B.T., Disteche, C.M., Lau, E.C., and Snead, L.M.: Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.Genomics 10: 23–28, 1991.

    Google Scholar 

  • Chapman, V.M., Stephenson, D.A., Mullins, L.J., Keitz, B.T., Disteche, C., and Orkin, S.H.: Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice.Genomics 9: 309–313, 1991.

    Google Scholar 

  • Chapman, V.M., Kratzer, P.G., and Quarantillo, B.A.: Electrophoretic variation for X chromosome-linked hypoxanthine phosphoribosyl transferase (hprt) in wild-derived mice.Genetics 103: 787–795, 1983.

    Google Scholar 

  • Cox, D.R., and Epstein, C.J.: Comparative gene mapping of human chromosome 21 and mouse chromosome 16.Ann NY Acad Sci 450: 169–177, 1985.

    Google Scholar 

  • Dautigny, A., Mattei, M.G., Morello, D., Alliel, P.M., Pham-Dinh, D., Amar, L., Arnaud, D., Simon, D., Mattei, J-F., Guenet, J-L., Jolles, P., and Avner, P.: The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice.Nature 321: 867–869, 1986.

    Google Scholar 

  • Davies, K.E., Mandel, J.L., Monaco, A.P., Nussbaum, R.L., and Willard, H.F.: Report of the committee on the genetic constitution of the X chromosome.Cytogenet Cell Genet 55: 254–313, 1990.

    Google Scholar 

  • Derry, J.M.J. and Barnard, P.J.: Localisation of theCcg-1 gene on the mouse X chromosome.Cytogenet Cell Genet 51: 988, 1989.

    Google Scholar 

  • Derry, J.M.J., Ryder-Cook, A.S., Lubahn, D.B., French, F.S., Wilson, E.M., Page, D.C., and Barnard, P.J.: Localisation of the androgen receptor gene on the mouse X chromosome and its relationship to the X-linked zinc finger protein.Cytogenet Cell Genet 51: 988, 1989.

    Google Scholar 

  • Derry, J.M.J. and Barnard, P.J.: Mapping of the Glycine receptor α2 subunit gene and the GABAA α3 receptor subunit gene on the mouse X chromosome.Genomics 10: 593–597, 1991.

    Google Scholar 

  • Derry, J.M.J., Lan, N.C., Shih, J.C., Barnard, E.A., and Barnard, P.J.: Localisation of monoamine oxidase A and B genes on the mouse X chromosome.Nucl Acids Res 17: 8403, 1989.

    Google Scholar 

  • Disteche, C.M., Kunkel, L.M., Lojeswki, A., Orkin, S.H., Eisenhard, M., Sahar, E., Travis, B., and Latt, S.A.: Isolation of mouse X-chromosome specific DNA from an X-enriched lambda phage library derived from flow sorted chromosomes.Cytometry 2: 282–286, 1982.

    Google Scholar 

  • Disteche, C.M., Tantravahi, U., Gandy, S., Eisenhard, M., Adler, D., and Kunkel, L.M.: Isolation and characterisation of two repetitive DNA fragments located near the centromere of the mouse X chromosome.Cytogenet Cell Genet 39: 262–268, 1985.

    Google Scholar 

  • Disteche, C.M., McConnell, G.K., Grant, S.G., Stephenson, D.A., Chapman, V.M., Gandy, S., and Adler, D.A.: Comparison of the physical and recombination maps of the mouse X chromosome.Genomics 5: 177–184, 1989.

    Google Scholar 

  • Elliott, R., Stephenson, D.A., Grant, S.G., and Chapman, V.M.: Identification of an X-linked member of theOdc gene family.Mouse News Lett 80: 180–181, 1988.

    Google Scholar 

  • Filippi, M., Tribioli, C., and Toniolo, D.: Linkage and sequence conservation of the X-linked genesDXS253E (P3) andDXS254E (Gdx) in mouse and man.Genomics 7: 453–457, 1990.

    Google Scholar 

  • Fisher, E.M.C., Cavanna, J.S., and Brown, S.D.M.: Microdissection and microcloning of the mouse X chromosome.Proc Natl Acad Sci USA 82: 5486–5489, 1985.

    Google Scholar 

  • Fisher, E.M.C., Beer-Romero, P., Brown, L.G., Ridley, A., McNeil, J.A., Lawrence, J.B., Willard, H.F., Bieber, F.R., and Page, D.C.: Homologous ribosomal protein genes on the human X and Y chromosomes: Escape from X inactivation and implications for Turner Syndrome.Cell 63: 1205–1218, 1990.

    Google Scholar 

  • Garchon, H-J., Loh, E., Ho, W.Y., Amar, L., Avner, P., and Davis, M.M.: The XLR sequence family: Dispersion on the X and Y chromosomes of a large set of closely related sequences, most of which are pseudogenes.Nucl Acids Res 17: 9871–9888, 1989.

    Google Scholar 

  • Gaspar, M.L., Meo, T., and Tosi, M.: Structure and size distribution of the androgen receptor mRNA in wild-type andTfm/y mutant mice.Molec Endocrinol 4: 1600–1610, 1990.

    Google Scholar 

  • Grant, S.G. and Chapman, V.M.: Detailed genetic mapping of the A-raf proto-oncogene on the mouse X chromosome.Oncogene, in press, 1991.

  • Grant, S.G., Mattei, M-F., Galland, F., Stephenson, D.A., Keitz, B.T., Birnbaum, D., and Chapman, V.M.: Localisation of the mouseMcf-2 (Dbl) proto-oncogene within a conserved linkage group on the mouse X chromosome.Cytogenet Cell Genet 54: 175–181, 1990.

    Google Scholar 

  • Hamvas, R.M.J., Keer, J.T., Brockdorff, N., and Brown, S.D.M.: The genetic mapping of anEag I linking clone, EM131, to theZfx/Ar cluster of the mouse X chromosome.Mouse Genome 87: 114, 1990.

    Google Scholar 

  • Heilig, R., Lemaire, C., Mandel, J.L., Dandalo, L., Amar, L., and Avner, P.: Localisation of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome.Nature 328: 168–170, 1987.

    Google Scholar 

  • Herman, G.E. and Walton, S.J.: Close linkage of the murine locus Bare Patches to the X-linked visual pigment gene: Implications for mapping human X-linked dominant Chondrodysplasia Punctata.Genomics 7: 307–312, 1990.

    Google Scholar 

  • Herman, G.E., Faust, C.J., Darlison, M.G., and Barnard, E.A.: Genetic mapping of the mouse X chromosome in the region homologous to human Xq27–Xq28.Genomics 9: 670–677, 1991.

    Google Scholar 

  • Hillyard, A.L., Doolittle, D.P., Davisson, M.T., and Roderick, T.H.: Locus map of mouse with comparative map points of human on mouse.Mouse Genome 87: 14–27, 1990.

    Google Scholar 

  • Johnson, G.G., Kronert, W.A., Bernstein, S.I., Chapman, V.M., and Smith, K.D.: Altered turnover of allelic variants of hypoxanthine phosphoribosyltransferase is associated with N-terminal amino acid sequence variation.J Biol Chem 263: 9079–9082, 1988.

    Google Scholar 

  • Keer, J.T., Hamvas, R.M.J., Brockdorff, N., Page, D., Rastan, S., and Brown, S.D.M.: Genetic mapping in the region of the mouse X-inactivation center.Genomics 7: 566–572, 1990.

    Google Scholar 

  • Lau, E.C., Mohandas, T.K., Shapito, L.J., Slavkin, H.C., and Snead, M.L.: Human and mouse amelogenin loci are on the sex chromosomes.Genomics 4: 162–168, 1989.

    Google Scholar 

  • Love, J.M., Knight, A.M., McAleer, M.A., and Todd, J.A.: Toward construction of a high resolution map of the mouse genome using PCR-analysed microsatellites.Nucl Acids Res 18: 4123–4130, 1990.

    Google Scholar 

  • Lyon, M.F., Zenthon, J., Evans, E.P., Burtenshaw, M.D., Wareham, K.A., and Williams, E.D.: Lack of inactivation of a mouse X-linked gene physically separated from the inactivation centre.J Embryol Exp Morph 97: 75–85, 1986.

    Google Scholar 

  • Lyon, M.F., Zenthon, J., Burtenshaw, M.D., and Evans, E.P.: Localisation of theHprt locus by in situ hybridisation and distribution of loci on the mouse X-chromosome.Cytogenet Cell Genet 44: 163–166, 1987.

    Google Scholar 

  • Lyon, M.F., Peters, J., Glenister, P.H., Ball, S., and Wright, E.: The scurfy mouse mutant has previously unrecognised hematological abnormalities and resembles Wiskott-Aldrich syndrome.Proc Natl Acad Sci USA 87: 2433–2437, 1990.

    Google Scholar 

  • Mandel, J-L., Willard, H.F., Nussbaum, R.L., Romeo, G., Puck, J.M., and Davies, K.E.: Report of the committee on the genetic constitution of the X chromosome.Cytogenet Cell Genet 51: 384–437, 1989.

    Google Scholar 

  • Minna, J.D., Marshall, T.H., Shaffer-Berman, P.V.: Chinese hamster X mouse hybrid cell lines segregating mouse chromosomes and isozymes.Som Cell Genetics 4: 355–369, 1975.

    Google Scholar 

  • Mitchell, M., Simon, D., Affara, N., Ferguson-Smith, M., Avner, P., and Bishop, C.: Localisation of murine X and autosomal sequences homologous to the human Y located testis-determining region.Genetics 121: 803–809, 1989.

    Google Scholar 

  • Mullins, L.J., Grant, S.G., Stephenson, D.A., and Chapman, V.M.: Multilocus molecular map of the mouse X chromosome.Genomics 3: 187–194, 1988.

    Google Scholar 

  • Mullins, L.J., Stephenson, D.A., Grant, S.G., and Chapman, V.M.: Efficient linkage of 10 loci in the proximal region of the mouse X chromosome.Genomics 7: 19–30, 1990.

    Google Scholar 

  • Nagamine, C.M., Chan, K., Kozak, C.A., and Lau, U.F.: Chromosome mapping and expression of a putative testis-determining gene in mouse.Science 243: 80–83, 1989.

    Google Scholar 

  • Nasir, J., Fisher, E.M.C., Brockdorff, N., Disteche, C.M., Lyon, M.F., and Brown, S.D.M.: Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome.Proc Natl Acad Sci USA 87: 399–403, 1990.

    Google Scholar 

  • Nielsen, J.T. and Chapman, V.M.: Electrophoretic variation for X-chromosome linked phosphoglycerate kinase (Pgk-1) in the mouse.Genetics 87: 319–325, 1977.

    Google Scholar 

  • Ozcelik, T., Lafreniere, R.G., Archer, B.T., Johston, P.A., Willard, H.F., Francke, U., and Sudhof, T.C.: Synaptophysin: Structure of the human gene and assignment to the X chromosome in man and mouse.Am J Hum Genet 47: 551–561, 1990.

    Google Scholar 

  • Page, D.C., Disteche, C.M., Simpson, E.M., de la Chapelle, A., Anderson, M., Alitalo, T., Brown, L.G., Green, P., Akots, G.: Chromosomal localisation ofZFX—a human gene that escapes X inactivation—and its murine homologs.Genomics 7: 37–46, 1990.

    Google Scholar 

  • Peters, J., Ball, S.T., Charles, D.J., Pretsch, W., Bulfield, G., Miller, D., and Chapman, V.M.: The localisation ofG6pd, glucose-6-phosphate dehydrogenase, andmdx, muscular dystrophy in the mouse X chromosome.Genet Res 52: 195–201, 1988.

    Google Scholar 

  • Ryder-Cook, A.S., Sicinski, P., Thomas, K., Davies, K.E., Worton, R.G., Barnard, E.A., Darlison, M.G., and Barnard, P.J.: Localisation of themdx mutation within the mouse dystrophin gene.EMBO J 7: 3017–3021, 1988.

    Google Scholar 

  • Sicinski, P., Geng, Y., Ryder-Cook, A.S., Barnard, E.A., Darlison, M.G., and Barnard, P.J.: The molecular basis of muscular dystrophy in themdx mouse: A point mutation.Science 244: 1578–1580, 1989.

    Google Scholar 

  • Siracusa, L.D., Rosner, M.H., Vigano, M.A., Gilbert, D.J., Staudt, L.M., Copeland, N.G., and Jenkins, N.A.: Chromosomal location of the Octamer transcription factors,Otf-1, Otf-2 andOtf-3 defines multipleOtf-3-related sequences dispersed in the genome.Genomics 10: 313–326, 1991.

    Google Scholar 

  • Stephenson, D.A., Elliott, R.W., Chapman, V.M., and Grant, S.G.: Identification of an X-linked member of theOdc gene family in the mouse.Nucl Acids Res 16: 1642, 1988.

    Google Scholar 

  • Stephenson, D.A., Keitz, B., Grant, S.G., Mullins, L.J., and Chapman, V.M.: Linkage analysis of the X-linked gene involved in the initiation of transition from G1 to S phase of the cell cycle.Mouse News Lett 86: 255, 1990.

    Google Scholar 

  • Taketo, M. and Tanaka, M.: A cellular enhancer of retrovirus gene expression in embryonal carcinoma cells.Proc Natl Acad Sci USA 84: 3748–3752, 1987.

    Google Scholar 

  • Veres, G., Gibbs, R.A., Scherer, S.E., and Caskey, C.T.: The molecular basis of the sparse fur mouse mutation.Science 237: 415–417, 1987.

    Google Scholar 

  • Wiles, M.V., Alexander, C.M., and Goddfellow, P.N.: Isolation of an abundantly expressed sequence from the human X chromosome by differential screening.Som Cell Mol Genet 14: 31–39, 1988.

    Google Scholar 

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Committee Members: D. Adler, P.J. Barnard, Y. Boyd, N. Brockdorff, J. Derry, C. Disteche, C. Faust, M.F. Lyon, S. Rastan, M. Seldin and L. Siracusa.

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Brown, S.D.M., Avner, P., Chapman, V.M. et al. Mouse X chromosome. Mammalian Genome 1 (Suppl 1), S318–S331 (1991). https://doi.org/10.1007/BF00656501

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