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Influence of Exon Duplication on Intron and Exon Phase Distribution

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Abstract.

Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness. All of the nonrandomness is probably due to both the processes of exon duplication and shuffling. A quantitative estimation of exon duplications in the human genome and their influence on the intron and exon phase distributions has been analyzed. According to our estimation, the proportion of duplicated exons in the human genome constitutes at least 6% of the total. Generalizing the particular case of exon duplication to the more common event of exon shuffling, we modeled and analyzed the influence of exon shuffling on intron phase distribution.

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Authors and Affiliations

  1. Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Academy of Sciences of Russia, Moscow 123182, Russia, , , , , , RU

    Alexey Fedorov

  2. Laboratory of Isotopic Research, V.A. Engelhardt Institute of Molecular Biology, Academy of Sciences of Russia, Moscow 117984, Russia, , , , , , RU

    Larisa Fedorova

  3. Laboratory of non-linear optical frequency conversion, Industrial Institute, Zaporozhye 330006, Ukraine, , , , , , UA

    Valery Starshenko

  4. Department of Biopolymer Function and Structure Research, Institute of Molecular Genetics, Academy of Sciences of Russia, Moscow 123182, Russia, , , , , , RU

    Vadim Filatov & Eugeni Grigor'ev

Authors
  1. Alexey Fedorov
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  2. Larisa Fedorova
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  3. Valery Starshenko
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  4. Vadim Filatov
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  5. Eugeni Grigor'ev
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Received: 28 March 1997 / Accepted: 9 July 1997

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Fedorov, A., Fedorova, L., Starshenko, V. et al. Influence of Exon Duplication on Intron and Exon Phase Distribution. J Mol Evol 46, 263–271 (1998). https://doi.org/10.1007/PL00006302

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  • DOI: https://doi.org/10.1007/PL00006302

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