Abstract
We determined vitamin D receptor (VDR) gene alleles (based on the BsmI restriction site polymorphism), duodenal mucosal receptor density, bone mass at spine and total body, and body size in 32 healthy premenopausal females. While we found no relationship between allele and receptor density in duodenal mucosa, bone mineral content (BMC) at both spine and total body was significantly associated with VDR gene alleles. BMC was highest for the bb allele, lowest for BB, and intermediate for Bb. A similar association was noted between allele and body size variables, particularly weight. When BMC was adjusted for body weight, the association with VDR polymorphism disappeared. The VDR gene polymorphism may be affecting bone mass not through classical nutritional mechanisms (e.g., intestinal calcium absorption), but through an influence on body size.
References
Morrison NA, Qi JC, Tokita A, Kelly L, Eisman JA (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367:284–287.
Hustmyer FG, Peacock M, Hui S, Johnston CC Jr, Christian J (1994) Bone mineral density in relation to polymorphism at the vitamin D receptor gene locus. J Clin Invest 94:2130–2134
Spector TD, Keen RW, Arden NK, et al (1994) Vitamin D receptor gene (VDR) alleles and bone density in postmenopausal women: a UK twin study. J Bone Miner Res 9:S143.
Barger-Lux MJ, Heaney RP, Lanspa SJ, Healy JC, DeLuca HF (1995) An investigation of sources of variation in calcium absorption efficiency. J Clin Endocrinol Metab 80:406–411.
Sandgren ME, DeLuca HF (1989) An immunoradiometric assay for 1,25-dihydroxyvitamin D3 receptor. Analytical Biochem 183:57–63.
Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual. 2nd edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
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Barger-Lux, M.J., Heaney, R.P., Hayes, J. et al. Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density. Calcif Tissue Int 57, 161–162 (1995). https://doi.org/10.1007/BF00298438
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DOI: https://doi.org/10.1007/BF00298438