Abstract
The effect was studied of various polyvalent metal ions on the metastability of a calcification buffer. At concentration of 1 μM or less, Pb2+, Fe2+, Fe3+, Cr3+, Bi3+ and Al3+ ions were found to destabilize the buffer. The results suggest that insoluble phosphates formed by these ions initiate the precipitation of calcium apatite. The implications of these findings to pathological calcification and calciphylaxis are discussed.
Résumé
L'action de divers ions métalliques polyvalents sur les propriétés métastables d'un tampon calcifiable a été étudiée. A des concentrations de 1 μM ou moins, les ions Pb2+, F2+, Fe3+, Cr3+, Bi3+ et Al3+ déstabilisent le tampon. Il semble que les phosphates insolubles formés par ces ions déclanchent la précipitation de l'apatite. L'importance de ces résultats dans l'étiologie des calcifications pathologiques et la calciphylaxie est décrite.
Zusammenfassung
Die Wirkung von verschiedenen polyvalenten Metallionen auf die Metastabilität eines Calcifikationspuffers wurde untersucht. Bei Konzentrationen von 1 μM oder weniger wird der Puffer durch Pb2+, Fe2+, Fe2+, Cr3+, Bi3+ und Al3+ entstabilisiert. Die Resultate lassen vermuten, daß unlösliche Phosphate, die mit diesen Ionen entstehen, eine Fällung von Apatit veranlassen. Die Bedeutung dieser Befunde bei pathologischen Verkalkungen und Calciphylaxis werden besprochen.
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This work was supported in part by the European Atomic Energy Community (EURATOM), Brussels, Belgium.
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Bachra, B.N., van Harskamp, G.A. The effect of polyvalent metal ions on the stability of a buffer system for calcificationin vitro . Calc. Tis Res. 4, 359–365 (1969). https://doi.org/10.1007/BF02279138
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DOI: https://doi.org/10.1007/BF02279138