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Identification of decomposition products of 1,1′-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome

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References

  • Barrows TH, Farina PR, Chrzanowski L, Benkovic PA, and Benkovic SJ (1976) Studies on models for tetrahydrofolic acid. J. Am Chem Soc 98:3678–3687

    Google Scholar 

  • Belongia EA, Hedberg MS, Gleich GJ, White KE, Mayeno AN, Loegering DA, Dunnette SL, Pirie PL, MacDonald KL, Osterholm MT (1990) An investigaion of the Eosinophiliamyalgia syndrome associated with tryptophan use. N Engl J Med 323:357–365

    Google Scholar 

  • Brehm WJ, and Lindwall H (1950) Carboline syntheses. J Org Chem 15:685–694

    Google Scholar 

  • Centersfor Disease Control, Morb Mortal Wkly Rep (1990) 39:589

    Google Scholar 

  • Centers for Disease Control, Morb Mortal Wkly Rep (1990) 39:789

    Google Scholar 

  • Colthup NL, Daly LH, and Wiberly SE (1964) Introduction to Infrared and Raman Spectroscopy. Academic Press, New York

    Google Scholar 

  • Gross VH, and Gloede J (1966) Preparation of N-functional derivatives of glyoxylic acid. Angew Chem Internat Edit 5:837–845

    Google Scholar 

  • Mayeno AN, Lin F, Foote CS, Loegering DA, Ames MM, Hedberg CW, Gleich GJ (1990) Characterization of “peak E,” anovel amino acid associated with eosinophilia-myalgiasyndrome. Science 250:1707–1708

    Google Scholar 

  • Slutsker L, Hoesly FC, Miller L, Williams LP, Watson JC, Fleming DW (1990) Eosinophilia myalgia syndrome associated with exposure to tryptophan from a single manufacturer. JAMA 264:213–217

    Google Scholar 

  • Sakimoto K (1991) The cause of the eosinophilia myalgia syndrome associated with tryptophan use. N Engl J Med 323:992–993

    Google Scholar 

  • Smith MF, Mazzola EP, Farrell TJ, Sphon JA, Page SW, Ashley DL, Sirimanne SR, Hill RH, Needham LL (1991) 1,1′-Ethylidenebis-(L-tryptophan), structural determination of contaminant “97” — implicated in the eosinophilia-myalgia syndrome (EMS). Tetrahedron Letters 32:991–994

    Google Scholar 

  • Swygert LA, Maes EF, Sewell LE, Miller L, Falk H, Kilbourne EM (1990) Eosinophilia myalgia syndrome. JAMA 264:1698–1703

    Google Scholar 

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Authors and Affiliations

  1. Center for Environmental Health and Injury Control, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, 30333, Atlanta, Georgia, USA

    William J. Driskell, David L. Ashley, James Grainger, Sarath R. Sirimanne, Larry L. Needham & Robert H. Hill Jr.

  2. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 20204, Washington, DC, USA

    Eugene P. Mazzola & Sam W. Page

Authors
  1. William J. Driskell
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  2. David L. Ashley
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  3. James Grainger
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  4. Sarath R. Sirimanne
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  5. Eugene P. Mazzola
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  6. Sam W. Page
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  7. Larry L. Needham
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  8. Robert H. Hill Jr.
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Driskell, W.J., Ashley, D.L., Grainger, J. et al. Identification of decomposition products of 1,1′-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. Bull. Environ. Contam. Toxicol. 48, 679–687 (1992). https://doi.org/10.1007/BF00195987

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  • DOI: https://doi.org/10.1007/BF00195987

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