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Tumour marking properties of different haematoporphyrins and tetrasulfonated phthalocyanine—A comparison

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Abstract

Several photosensitizers were screened for their tumour-marking ability using laserinduced fluorescence in Wistar/Furth rats bearing subcutaneous adenocarcinomas inoculated in muscle. Of the studied photosensitizers, dihaematoporphyrin ether appeared to exhibit the best tumour-demarcation properties. Polyhaematoporphyrin ester and tetrasulfonated phthalocyanine were almost as good although the fluorescence yield was much lower. Monomeric haematoporphyrin also showed some tumour-marking qualities. By forming fluorescence intensity ratios, information from both the blue and the red spectral regions were used to provide the highest tumour-to-muscle contrast. Two excitation wavelengths were used, of which 337 nm rather than 405 nm excitation light seemed to yield a better tumour demarcation, due to a greater difference in the superimposing autofluorescence between tumour and surrounding tissue. The study included measurements on many inner organs in an attempt to gain a better understanding of the interaction between the drugs and various kinds of tissue.

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Authors and Affiliations

  1. Department of Physics, Lund Institute of Technology, P.O. Box 118, S-221 00, Lund

    S. Andersson-Engels, J. Ankerst, J. Johansson, K. Svanberg & S. Svanberg

  2. Department of Medicine, Lund University Hospital, S-221 85, Lund, Sweden

    J. Ankerst & K. Svanberg

  3. Department of Oncology, Lund University Hospital, S-221 85, Lund, Sweden

    K. Svanberg

Authors
  1. S. Andersson-Engels
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  2. J. Ankerst
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  3. J. Johansson
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  4. K. Svanberg
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  5. S. Svanberg
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Andersson-Engels, S., Ankerst, J., Johansson, J. et al. Tumour marking properties of different haematoporphyrins and tetrasulfonated phthalocyanine—A comparison. Laser Med Sci 4, 115–123 (1989). https://doi.org/10.1007/BF02032608

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  • DOI: https://doi.org/10.1007/BF02032608

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