Summary
Developing transverse (T) tubules are found in embryonic guinea pig ventricular myocardium after approximately eight weeks of gestation. By the time of birth (nine weeks total gestation), longitudinally-oriented axial tubules connected to the T tubules also have formed, and the majority of cells closely resemble those of the adult. The form taken by the developing T and axial tubules suggests that they are generated in a manner similar to that for T tubules in chick and rat skeletal muscle, namely by repeated formation of caveolae.
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Supported by Public Health Service grant HL-11155. Dr. Forbes was a postdoctoral fellow (1-FO2-HL-51147-01) of the PHS during part of this study.
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Forbes, M.S., Sperelakis, N. The presence of transverse and axial tubules in the ventricular myocardium of embryonic and neonatal guinea pigs. Cell Tissue Res. 166, 83–90 (1976). https://doi.org/10.1007/BF00215127
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DOI: https://doi.org/10.1007/BF00215127