Abstract
We describe the first polymorphism in the 5′ flanking region of the corticotropin releasing hormone (CRH) gene. DNA sequencing analysis identified a T → G base substitution in the 5′ flanking region of the gene. This substitution leads to the loss of anXmnI site at position 255 of the Genbank entry X67661. The frequency analysis in 32 Caucasians revealed that it is a rare polymorphism, with only three observed heterozygous individiuals for this polymorphism.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Arbiser JL, Morton CC, Bruns GA, Majzoub JA (1988) Human corticotropin releasing hormone gene is located on the long arm of chromosome 8. Cytogenet Cell Genet 47:113–116
Chikanza IC, Petrou P, Kingsley G, Chrousos GP, Panayi GS (1992) Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 35:1281–1288
Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463–5467
Vamvakopoulos NC, Chrousos GP (1993) Structural organization of the 5′ flanking region of the human corticotropin releasing hormone gene. DNA Seq 4:197–206
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Baerwald, C.G.O., Panayi, G.S. & Lanchbury, J.S. A newXmnI polymorphism in the regulatory region of the corticotropin releasing hormone gene. Hum Genet 97, 697–698 (1996). https://doi.org/10.1007/BF02281888
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02281888