Abstract
We describe seven restriction fragment length polymorphisms (RFLPs) in the Leukemia Inhibitory Factor (LIF) gene region. These new markers, found using a cosmid contig, have been used to map precisely the chromosome 22 long arm.
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Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms Am J Hum Genet 32:314–331
Budarf M, Emanuel BS, Mohandas T, Goeddel DV, Lowe DG (1989) Human differentiation-stimulating factor (leukemia inhibitory factor, human interleukin DA) gene maps distal to the Ewing sarcoma breakpoint on 22q. Cell Genet 52:19–22
Gearing DP, Gough NM, King JA, Hilton DJ, Nicola NA, Simpson RJ, Nice EC, Kelso A, Metcalf D (1987) Molecular cloning and expression of cDNA encoding a murine myeloid leukemia inhibitory factor (LIF). EMBO J 6:3995–4002
Krapcho K, Nakamura Y, Fujimoto E, Eldridge R, Leppert M, O'Connell P, Lathrop GM, Lalouel JM, White R (1988) Isolation and mapping of a polymorphic DNA sequence (pEFZS1) on chromosome 22. Nucleic Acids Res 16:5221
Lathrop GM, Lalouel JM, Julier C, Ott J (1985) Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am J Hum Genet 37:482–498
Moreau JF, Donaldson DD, Bennett F, Witek-Gianotti JA, Clark SC, Wong GG (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336:690–692
Narod SA, Parry DM, Parboosingh J, Lanoir GM, Ruttledge M, Fischer G, Eldridg R, Martuza L, Frontali M, Haines J, Gusella JF, Rouleau G (1992) Neurofibromatosis type 2 appears to be a genetically homogeneous disease. Am J Hum Genet 51:486–496
Rouleau GA, Merel P, Lutchman M, Sanson M, Zucman J, Marineau C, Hoang Xuan K, Demczuk S, Desmaze C, Plougastel B, Pulst SM, Lenoir G, Bijlsma E, Fashold R, Dumanski J, Jong P de, Parry D, Eldrige R, Aurias A, Delattre O, Thomas G (1993) Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363:515–521
Sutherland GR, Baker E, Hyland JV, Callen DF, Stahl J, Gough N (1989) The gene for human leukemia inhibitory factor (LIF) maps to 22q12. Leukemia 3:9–13
Tokino T, Takahashi E, Mori M, Tanigami A, Glaser T, Park JW, Jones C, Hori T, Nakamura Y (1991) Isolation and mapping of 62 new RFLP markers on human chromosome 11. Am J Genet 48:258–268
Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K, Haase VH, Ambrose CM, Munroe D, Bove C, Haines JL, Martuza RL, MacDonald ME, Seizinger BR, Short MP, Buckler AJ, Gusella JE (1993) A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72:791–800
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Moreau-Aubry, A., Andre, M.T., Devilder, M.C. et al. Characterization of several DNA polymorphic markers in the LIF gene region. Hum Genet 94, 450–451 (1994). https://doi.org/10.1007/BF00201613
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DOI: https://doi.org/10.1007/BF00201613