Abstract
A study on the presence of human papillomavirus (HPV) DNA sequences and focal epithelial hyperplasia (FEH) in a family of Venezuelan ancestry has revealed that FEH is an HPV-induced disease presenting familial aggregation. The genealogical evidence indicates a genetic predisposition to the disease.
References
Archard HO, Heck JW (1965) Focal epithelial hyperplasia: an unusual oral mucosal lesion found in Indian children. Oral Surg 20: 201–212
Beaudenon S, Praetorius F, Kremsdorf D, Lutzner M, Worsaae N, Pehaw-Arnaudet G, Orth G (1987) A new type of human papillomavirus associated with oral focal epithelial hyperplasia. Invest Dermatol 88: 130–135
Gomez A, Calle C, Arala G, Pindborg JT (1969) Focal epithelial hyperplasia in a half-breed familial of Colombians. J Am Dent Assoc 79: 79–83
Pfister H, Hettich I, Runne U, Gissmann L, Chilf GN (1983) Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. J Virol 47: 363–366
Pilgard G (1984) Focal epithelial hyperplasia. Oral Surg 57: 540–543
Praetorius-Clause F (1973) Geographical aspects of oral focal epithelial hyperplasia. Pathol Microbiol 39: 204–213
Premoli-De-Percoco G, Galindo I, Ramirez JL (1992) In situ hybridization with digoxigenin-labeled DNA probes for the detection of human papillomavirus-induced focal epithelial hyperplasia among Venezuelans. Virchows Archiv [A] 420: 295–300
Soneira A, Fonseca N (1964) Sobre una lesion de la mucosa oral en los ninos de la Mision los Angeles del Tokuko. Venezuela Odont 29: 109
Syrjanen S, Syrjanen K, Ikenberg H, Gissmann L, Lamberg M (1984) A human papillomavirus closely related to HPV 13 found in a focal epithelial hyperplasia lesion (Heck disease). Arch Dermatol Res 276: 199–200
Van Wyk CW, Staz J, Farman AG (1977) Focal epithelial hyperplasia in a group of south Africans: its ultrastructural features. J Oral Pathol 6: 14–24
Villiers EM de, Neumann C, Le JY, Weiduer H, Hausen H zur (1986) Infection of the oral mucosa with defined types of human papillomaviruses. Med Microbiol Immunol 174: 287–294
Williamson A-L, Dennis S (1991) The use of polymerase chain reaction for the detection of human papillomavirus type 13. J Virol Methods 31: 57–66
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Premoli-De-Percoco, G., Cisternas, J.P., Ramírez, J.L. et al. Focal epithelial hyperplasia: human-papillomavirus-induced disease with a genetic predisposition in a Venezuelan family. Hum Genet 91, 386–388 (1993). https://doi.org/10.1007/BF00217363
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00217363