Skip to main content
SpringerLink
Log in

The gene for the type II (p75) tumor necrosis factor receptor (TNF-RII) is localized on band 1p36.2–p36.3

  • Short Comunications
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

The gene encoding the type II (p75) tumor necrosis factor receptor (TNF-RII) has been localized on human chromosome 1, band 1p36.2 by nonradioactive in situ hybridization. The gene encoding the type I (p55) TNF-R, which is structurally homologous to the type II (p75) TNF-R, has been previously localized on chromosome 12 band 12p13. Thus, despite their probable common ancestry, the genes for the two TNF-Rs are localized on different chromosomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Camargo M, Cervenka J (1980) Pattern of chromosomal replication in synchronized lymphocytes. II. Replication map and replication model. Am J Hum Genet 34:757–780

    Google Scholar 

  • Cherif D, Julier C, Delattre O, Derré J, Lathrop GM, Berger R (1990) Simultaneous localization of cosmids and chromosome R-banding by fluorescence microscopy: application to regional mapping of human chromosome 11. Proc Natl Acad Sci USA 87:6639–6643

    Google Scholar 

  • D'Ancona CG, Chern CJ, Bann P, Croce CM (1977) Assignment of the human gene for enolase to region 1pter→p36 of chromosome 1. Cytogenet Cell Genet 18:327–332

    Google Scholar 

  • Dembic Z, Loetscher H, Gubler U, Pan Y-CE, Lahm H-W, Gentz R, Brockhaus M, Lesslauer W (1990) Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences. Cytokine 2:231–237

    Google Scholar 

  • Derré J, Kemper O, Cherif D, Nophar Y, Berger R, Wallach D (1991) The gene for the type 1 tumor necrosis factor receptor (TNF-RI) is localized on band 12p13. Hum Genet 87:231–233

    Google Scholar 

  • Engelmann H, Novick D, Wallach D (1990) Two tumor necrosis factor-binding proteins purified from human urine. J Biol Chem 265:1531–1536

    Google Scholar 

  • Feinberg AP, Vogelstein BA (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6–13

    CAS  PubMed  Google Scholar 

  • Hohmann H, Remy R, Brockhaus M, Loon APGM van (1989) Two different cell types have different major receptors for human tumor necrosis factor (TNF-α). J Biol Chem 254:14927–14934

    Google Scholar 

  • Kohno T, Brewer MT, Baker SL, Schwartz PE, King MW, Hale KK, Squires CH, Thompson RC, Vannice JL (1990) A second tumor necrosis factor receptor gene product can shed a naturally occurring necrosis factor inhibitor. Proc Natl Acad Sci USA 87:8331–8335

    Google Scholar 

  • Loetscher H, Pan Y-CE, Lahm H-W, Tabuchi H, Lesslauer W (1990) Molecular cloning and expression of the 55 kd tumor necrosis factor receptor. Cell 61:351–359

    PubMed  Google Scholar 

  • Nophar Y, Kemper O, Brakebusch C, Engelmann H, Zwang R, Aderka D, Holtmann H, Wallach D (1990) Soluble forms of tumor necrosis factor Receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor. Embo J 9:3269–3278

    Google Scholar 

  • Pinkel D, Straube T, Gray JW (1986) Cytogenetic analysis using quantitative high fluorescence hybridization. Proc Natl Acad Sci USA 83:2934–2938

    Google Scholar 

  • Reeves BR, Pickup VL (1980) The chromosome changes in nonBurkitt lymphomas. Hum Genet 53:349–355

    Google Scholar 

  • Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GHW, Gatanaga T, Granger GA, Lentz R, Raab H, Kohr WJ, Goeddel DV (1990) Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell 61:361–370

    Google Scholar 

  • Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Gooswin RG (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248:1019–1023

    Google Scholar 

  • Sundström C, Nilsson K (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937). Int J Cancer 17:565–577

    Google Scholar 

  • Welborn JL, Lewis JP, Jenks H, Walling P (1987) Diagnostic and rognostic significance of t(1;3)(p36;q21) in the disorders of hematopoiesis. Cytogenet Cell Genet 28:277–285

    Google Scholar 

  • Yamada K, Sugimoto E, Amano M, Imamura Y, Kubota T, Matsumoto M (1983) Two cases of acute promyelocytic leukemia with variant translocations: the importance of chromosome no 17 abnormality. Cancer Genet Cytogenet 9:93–99

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Genetics and Virology, The Weitzmann Institute of Science, Rehovot, Israel

    Oliver Kemper, Dorra Cherif, Harmut Engelmann & David Wallach

  2. Unité INSERM U. 301 and SDI No. 15954 I CNRS, Institut de Génétique Moléculaire, 27, Rue Juliette Dodu, F-75010, Paris, France

    Josette Derré & Roland Berger

Authors
  1. Oliver Kemper
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Josette Derré
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dorra Cherif
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Harmut Engelmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. David Wallach
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Roland Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kemper, O., Derré, J., Cherif, D. et al. The gene for the type II (p75) tumor necrosis factor receptor (TNF-RII) is localized on band 1p36.2–p36.3. Hum Genet 87, 623–624 (1991). https://doi.org/10.1007/BF00209026

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00209026

Keywords

Search

Navigation