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A new HaeIII polymorphism at the D21S13 locus

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Summary

DNA markers in the pericentromeric region of human chromosome 21 have shown linkage to a gene for Familial Alzheimer disease (FAD; St. George Hyslop et al. 1987). The limited informativeness of probes for the loci D21S13 and D21S16 have hindered precise mapping of the FAD locus and analysis of non-allelic heterogeneity in FAD (Schellenberg et al. 1988; St. George-Hyslop et al. 1987). We recently described a new EcoRII polymorphism at the D21S13 locus that was very informative in a large FAD pedigree (Pulst et al. 1990a, b). We now report another polymorphism for the D21S13 locus that further increases the informativeness of this locus.

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References

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Authors and Affiliations

  1. Division of Neurology, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA

    S. -M. Pulst, M. Ren & J. Greenwald

  2. Division of Medical Genetics, Cedars-Sinai Medical Center, University of California, 8700 Beverly Boulevard, 90048, Los Angeles, CA, USA

    J. R. Korenberg

Authors
  1. S. -M. Pulst
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  2. J. R. Korenberg
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  3. M. Ren
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  4. J. Greenwald
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Pulst, S.M., Korenberg, J.R., Ren, M. et al. A new HaeIII polymorphism at the D21S13 locus. Hum Genet 85, 671 (1990). https://doi.org/10.1007/BF00193597

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